Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 7/20 | 0.56 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.56 |
| ▸ | PFKFB2 | O60825 | 6/20 | 0.50 |
| ▸ | PFKFB1 | P16118 | 6/20 | 0.50 |
| ▸ | PFKFB3 | Q16875 | 6/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | NSD2 | O96028 | 2/20 | 0.45 |
| ▸ | AS3MT | Q9HBK9 | 2/20 | 0.45 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17536366 | 0.90 | MTNR1B (0.63) | MTNR1BMTNR1APFKFB2PFKFB1PFKFB3 | |
| SCHEMBL17350077 | 0.89 | PFKFB2 (0.49) | MTNR1BMTNR1APFKFB2PFKFB1PFKFB3 | |
| SCHEMBL4171293 | 0.84 | MTNR1B (0.58) | MTNR1BMTNR1APFKFB2PFKFB1PFKFB3 | |
| SCHEMBL17536367 | 0.83 | PFKFB1 (0.42) | MTNR1BMTNR1APFKFB2PFKFB1PFKFB3 | |
| SCHEMBL12594099 | 0.82 | PFKFB2 (0.44) | PFKFB2PFKFB1PFKFB3POLB | |
| SCHEMBL12594168 | 0.81 | PFKFB1 (0.47) | PFKFB2PFKFB1PFKFB3NSD2AS3MT | |
| SCHEMBL13720495 | 0.81 | PFKFB1 (0.47) | PFKFB2PFKFB1PFKFB3NSD2AS3MT | |
| SCHEMBL21908517 | 0.81 | PFKFB3 (0.46) | MTNR1BPFKFB2PFKFB1PFKFB3POLB | |
| SCHEMBL13720598 | 0.80 | AR (0.42) | PFKFB2PFKFB1PFKFB3HPGD | |
| SCHEMBL17350098 | 0.80 | AR (0.47) | PFKFB2PFKFB1PFKFB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160058737-A1 | IMIDAZOLIDINEDIONE DERIVATIVES | AUTIFONY THERAPEUTICS LIMITED (GB) | 2016-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160058737-A1 | IMIDAZOLIDINEDIONE DERIVATIVES | KCND3, KCNK3, KCNA3 | MTNR1B 1903/4885MTNR1A 2267/4885PFKFB2 3063/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.