Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PFKFB1 | P16118 | 5/20 | 0.42 |
| ▸ | PFKFB2 | O60825 | 4/20 | 0.42 |
| ▸ | PFKFB3 | Q16875 | 4/20 | 0.42 |
| ▸ | AR | P10275 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | IL18 | Q14116 | 1/20 | 0.40 |
| ▸ | PLA2G7 | Q13093 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17536365 | 0.90 | AR (0.54) | PFKFB1PFKFB2PFKFB3ARALDH1A1 | |
| SCHEMBL17536369 | 0.83 | MTNR1B (0.56) | PFKFB1PFKFB2PFKFB3POLBTP53 | |
| SCHEMBL12594099 | 0.81 | PFKFB2 (0.44) | PFKFB1PFKFB2PFKFB3ARLMNA | |
| SCHEMBL17350098 | 0.81 | AR (0.47) | PFKFB1PFKFB2PFKFB3ARLMNA | |
| SCHEMBL12594168 | 0.81 | PFKFB1 (0.47) | PFKFB1PFKFB2PFKFB3ARMAPT | |
| SCHEMBL13720495 | 0.81 | PFKFB1 (0.47) | PFKFB1PFKFB2PFKFB3ARMAPT | |
| SCHEMBL17350077 | 0.80 | PFKFB2 (0.49) | PFKFB1PFKFB2PFKFB3ALDH1A1POLB | |
| SCHEMBL21908517 | 0.80 | PFKFB3 (0.46) | PFKFB1PFKFB2PFKFB3ARLMNA | |
| SCHEMBL17350060 | 0.79 | ALDH1A1 (0.46) | ARLMNAMAPTALDH1A1MEN1 | |
| SCHEMBL13720598 | 0.79 | AR (0.42) | PFKFB1PFKFB2PFKFB3ARRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160058737-A1 | IMIDAZOLIDINEDIONE DERIVATIVES | AUTIFONY THERAPEUTICS LIMITED (GB) | 2016-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160058737-A1 | IMIDAZOLIDINEDIONE DERIVATIVES | KCND3, KCNK3, KCNA3 | PFKFB1 2930/4885PFKFB2 3063/4885PFKFB3 2098/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.