SCHEMBL17536620

SCHEMBL17536620

C[Si](C)(C#Cc1cccnc1)c1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 4/20 0.47
CYP2A6 P11509 6/20 0.47
CHRNB2 P17787 5/20 0.47
CHRNA4 P43681 5/20 0.47
CYP2C9 P11712 3/20 0.47
CYP2B6 P20813 3/20 0.47
CYP2C19 P33261 3/20 0.47
CYP2D6 P10635 3/20 0.46
CYP2E1 P05181 2/20 0.46
CYP3A4 P08684 2/20 0.46
CYP1A2 P05177 2/20 0.45
CYP2C8 P10632 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17536636 0.83 APP (0.48) GRM5CYP2C9CYP2C19CYP2D6CYP3A4
SCHEMBL30694380 0.80 CYP2A6 (0.55) GRM5CYP2A6CHRNB2CHRNA4CYP2C9
SCHEMBL2922495 0.80 CYP2A6 (0.55) GRM5CYP2A6CHRNB2CHRNA4CYP2C9
SCHEMBL6365168 0.79 APP (0.48) GRM5CYP2C9CYP2C19CYP2D6CYP3A4
SCHEMBL17536641 0.78 GRM5 (0.39) GRM5CYP2C9CYP2C19CYP2D6CYP3A4
SCHEMBL401836 0.77 GRM5 (0.64) GRM5CYP2A6CHRNB2CHRNA4CYP2C9
SCHEMBL31673222 0.77 GRM5 (0.64) GRM5CYP2A6CHRNB2CHRNA4CYP2C9
SCHEMBL22548041 0.75 GRM5 (0.41) GRM5
SCHEMBL3796332 0.74 CYP2A6 (0.67) GRM5CYP2A6CHRNB2CHRNA4CYP2C9
SCHEMBL30825998 0.74 GRM5 (0.49) GRM5CYP2A6CHRNB2CHRNA4CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3189063-B1 BASE-CATALYZED SILYLATION OF TERMINIAL ALKYNE C-H BONDS CALIFORNIA INST OF TECHN (US) 2019-08-14 EP disclosed
US-10072030-B2 Base-catalyzed silylation of terminal alkyne C—H bonds CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2018-09-11 US disclosed
EP-3189063-A1 BASE-CATALYZED SILYLATION OF TERMINIAL ALKYNE C-H BONDS California Institute of Technology (US) 2017-07-12 EP disclosed
US-20170088563-A1 BASE-CATALYZED SILYLATION OF TERMINAL ALKYNE C-H BONDS NATIONAL SCIENCE FOUNDATION 2017-03-30 US disclosed
US-20170088563-A1 BASE-CATALYZED SILYLATION OF TERMINAL ALKYNE C-H BONDS NATIONAL SCIENCE FOUNDATION 2017-03-30 US disclosed
US-9556206-B2 Base-catalyzed silylation of terminal alkyne C—H bonds CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2017-01-31 US disclosed
US-9556206-B2 Base-catalyzed silylation of terminal alkyne C—H bonds CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2017-01-31 US disclosed
WO-2016036685-A1 BASE-CATALYZED SILYLATION OF TERMINIAL ALKYNE C-H BONDS CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2016-03-10 WO disclosed
WO-2016036685-A1 BASE-CATALYZED SILYLATION OF TERMINIAL ALKYNE C-H BONDS CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2016-03-10 WO disclosed
US-20160060278-A1 BASE-CATALYZED SILYLATION OF TERMINAL ALKYNE C-H BONDS CALIFORNIA INSTITUTE OF TECHNOLOGY 2016-03-03 US disclosed
US-20160060278-A1 BASE-CATALYZED SILYLATION OF TERMINAL ALKYNE C-H BONDS CALIFORNIA INSTITUTE OF TECHNOLOGY 2016-03-03 US disclosed
US-20160060278-A1 BASE-CATALYZED SILYLATION OF TERMINAL ALKYNE C-H BONDS CALIFORNIA INSTITUTE OF TECHNOLOGY 2016-03-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160060278-A1 BASE-CATALYZED SILYLATION OF TERMINAL ALKYNE C-H BONDS ALKBH3, CA3, ALKBH2 GRM5 3797/4885CYP2A6 1907/4885CHRNB2 3220/4885
US-20170088563-A1 BASE-CATALYZED SILYLATION OF TERMINAL ALKYNE C-H BONDS ALKBH3, CA3, ALKBH2 GRM5 4034/4885CYP2A6 1691/4885CHRNB2 3388/4885
US-10072030-B2 Base-catalyzed silylation of terminal alkyne C—H bonds ALKBH3, CA3, ALKBH2 GRM5 4027/4885CYP2A6 1656/4885CHRNB2 3422/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.