SCHEMBL17536630

SCHEMBL17536630

C#Cc1cccc(C#C[Si](C)(C)c2ccccc2)c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 1/20 0.39
NPC1 O15118 2/20 0.34
RAB9A P51151 2/20 0.34
SMN1; SMN2 Q16637 2/20 0.34
MEN1 O00255 2/20 0.34
KMT2A Q03164 2/20 0.34
CA12 O43570 1/20 0.34
CA1 P00915 1/20 0.34
CA2 P00918 1/20 0.34
CA9 Q16790 1/20 0.34
CA14 Q9ULX7 1/20 0.34
KDM4E B2RXH2 1/20 0.34
ALDH1A1 P00352 1/20 0.34
TP53 P04637 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2D6 P10635 1/20 0.34
CYP2C9 P11712 1/20 0.34
PKM P14618 1/20 0.34
HPGD P15428 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17536641 0.91 GRM5 (0.39) NPC1RAB9ASMN1; SMN2MEN1KMT2A
SCHEMBL17536636 0.82 APP (0.48) NPC1RAB9ASMN1; SMN2MEN1KMT2A
SCHEMBL17552563 0.80 GRM5 (0.50) NPC1RAB9ASMN1; SMN2TP53CYP2D6
SCHEMBL6365168 0.78 APP (0.48) NPC1RAB9ASMN1; SMN2MEN1KMT2A
SCHEMBL4734252 0.72 CA12 (0.41) FFAR1CA12CA1CA2CA9
SCHEMBL17552564 0.72 ALDH1A1 (0.42) FFAR1NPC1RAB9ASMN1; SMN2MEN1
SCHEMBL17536620 0.71 GRM5 (0.47) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL17552568 0.71 CYP2A6 (0.44) FFAR1NPC1RAB9ASMN1; SMN2MEN1
SCHEMBL3947297 0.71 ESR1 (0.42) NPC1RAB9ASMN1; SMN2MEN1KMT2A
SCHEMBL23867871 0.71 APP (0.50) NPC1RAB9ASMN1; SMN2MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3189063-B1 BASE-CATALYZED SILYLATION OF TERMINIAL ALKYNE C-H BONDS CALIFORNIA INST OF TECHN (US) 2019-08-14 EP disclosed
US-10072030-B2 Base-catalyzed silylation of terminal alkyne C—H bonds CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2018-09-11 US disclosed
EP-3189063-A1 BASE-CATALYZED SILYLATION OF TERMINIAL ALKYNE C-H BONDS California Institute of Technology (US) 2017-07-12 EP disclosed
US-20170088563-A1 BASE-CATALYZED SILYLATION OF TERMINAL ALKYNE C-H BONDS NATIONAL SCIENCE FOUNDATION 2017-03-30 US disclosed
US-20170088563-A1 BASE-CATALYZED SILYLATION OF TERMINAL ALKYNE C-H BONDS NATIONAL SCIENCE FOUNDATION 2017-03-30 US disclosed
US-9556206-B2 Base-catalyzed silylation of terminal alkyne C—H bonds CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2017-01-31 US disclosed
US-9556206-B2 Base-catalyzed silylation of terminal alkyne C—H bonds CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2017-01-31 US disclosed
WO-2016036685-A1 BASE-CATALYZED SILYLATION OF TERMINIAL ALKYNE C-H BONDS CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2016-03-10 WO disclosed
WO-2016036685-A1 BASE-CATALYZED SILYLATION OF TERMINIAL ALKYNE C-H BONDS CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2016-03-10 WO disclosed
US-20160060278-A1 BASE-CATALYZED SILYLATION OF TERMINAL ALKYNE C-H BONDS CALIFORNIA INSTITUTE OF TECHNOLOGY 2016-03-03 US disclosed
US-20160060278-A1 BASE-CATALYZED SILYLATION OF TERMINAL ALKYNE C-H BONDS CALIFORNIA INSTITUTE OF TECHNOLOGY 2016-03-03 US disclosed
US-20160060278-A1 BASE-CATALYZED SILYLATION OF TERMINAL ALKYNE C-H BONDS CALIFORNIA INSTITUTE OF TECHNOLOGY 2016-03-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160060278-A1 BASE-CATALYZED SILYLATION OF TERMINAL ALKYNE C-H BONDS ALKBH3, CA3, ALKBH2 FFAR1 4722/4885NPC1 1295/4885RAB9A 3540/4885
US-20170088563-A1 BASE-CATALYZED SILYLATION OF TERMINAL ALKYNE C-H BONDS ALKBH3, CA3, ALKBH2 FFAR1 4683/4885NPC1 1349/4885RAB9A 3558/4885
US-10072030-B2 Base-catalyzed silylation of terminal alkyne C—H bonds ALKBH3, CA3, ALKBH2 FFAR1 4674/4885NPC1 1351/4885RAB9A 3522/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.