Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 4/20 | 0.50 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.50 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.50 |
| ▸ | FAAH | O00519 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.50 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17537169 | 0.94 | GABRA1 (0.47) | GABRA1GABRB2CYP3A4CA2GABRG2 | |
| SCHEMBL17537155 | 0.86 | CA2 (0.34) | GABRA1GABRB2CYP3A4CA2GABRG2 | |
| SCHEMBL17537112 | 0.85 | GABRA1 (0.52) | GABRA1GABRB2CYP3A4CA2GABRG2 | |
| SCHEMBL17972911 | 0.83 | CYP3A4 (0.37) | GABRA1GABRB2CYP3A4CA2GABRG2 | |
| SCHEMBL17537162 | 0.80 | GABRA1 (0.46) | GABRA1GABRB2CYP3A4CA2GABRG2 | |
| SCHEMBL19111886 | 0.79 | GABRA1 (0.48) | GABRA1GABRB2CYP3A4CA2GABRG2 | |
| SCHEMBL7745836 | 0.77 | GABRA1 (0.64) | GABRA1GABRB2CYP3A4CA2GABRG2 | |
| SCHEMBL56957 | 0.77 | GABRA1 (0.64) | GABRA1GABRB2CYP3A4CA2GABRG2 | |
| SCHEMBL17537184 | 0.77 | CA2 (0.39) | GABRA1GABRB2CA2TSHRALDH1A1 | |
| SCHEMBL13640241 | 0.76 | GABRA1 (0.57) | GABRA1GABRB2CYP3A4CA2GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3189834-B1 | USE OF GABAA RECEPTOR REINFORCING AGENT IN PREPARATION OF SEDATIVE AND ANESTHETIC MEDICAMENT | HAISCO INNOVATIVE PHARMACEUTICAL PTE LTD (SG) | 2024-01-17 | — | — | EP | disclosed |
| CN-113521038-A | Anesthetic pharmaceutical composition and application thereof | 海思科医药集团股份有限公司 | 2021-10-22 | — | — | CN | disclosed |
| US-10729666-B2 | Use of GABAA receptor reinforcing agent in preparation of sedative and anesthetic medicament | HAISCO CHENGDU PHARMACEUTICAL TECHNOLOGY CO., LTD. (CN) | 2020-08-04 | — | — | US | disclosed |
| US-10729666-B2 | Use of GABAA receptor reinforcing agent in preparation of sedative and anesthetic medicament | HAISCO CHENGDU PHARMACEUTICAL TECHNOLOGY CO., LTD. (CN) | 2020-08-04 | — | — | US | disclosed |
| CN-105384619-B | Isopropyl phenol derivative and preparation method thereof | 四川海思科制药有限公司 | 2020-05-29 | — | — | CN | disclosed |
| CN-105384607-B | A kind of cumene amphyl and preparation method thereof | 四川海思科制药有限公司 | 2019-08-16 | — | — | CN | disclosed |
| EP-2995604-B1 | PHENOL DERIVATIVE AND PREPARATION METHOD AND USE IN MEDICINE THEREOF | SICHUAN HAISCO PHARMACEUTICAL CO LTD (CN) | 2019-07-10 | — | — | EP | disclosed |
| EP-2995604-B1 | PHENOL DERIVATIVE AND PREPARATION METHOD AND USE IN MEDICINE THEREOF | SICHUAN HAISCO PHARMACEUTICAL CO LTD (CN) | 2019-07-10 | — | — | EP | disclosed |
| CN-105579034-B | A kind of GABAA receptor potentiators are used to prepare the purposes in the medicine of sedation anesthesia | 海思科医药集团股份有限公司 | 2018-05-15 | — | — | CN | disclosed |
| US-20170290781-A1 | USE OF GABAA RECEPTOR REINFORCING AGENT IN PREPARATION OF SEDATIVE AND ANESTHETIC MEDICAMENT | HAISCO INNOVATIVE PHARMACEUTICAL PTE. LTD. (SG) | 2017-10-12 | — | — | US | disclosed |
| EP-2995604-A1 | PHENOL DERIVATIVE AND PREPARATION METHOD AND USE IN MEDICINE THEREOF | Sichuan Haisco Pharmaceutical Co., Ltd. (CN) | 2016-03-16 | — | — | EP | disclosed |
| EP-2995604-A1 | PHENOL DERIVATIVE AND PREPARATION METHOD AND USE IN MEDICINE THEREOF | Sichuan Haisco Pharmaceutical Co., Ltd. (CN) | 2016-03-16 | — | — | EP | disclosed |
| WO-2016034079-A1 | USE OF GABAA RECEPTOR REINFORCING AGENT IN PREPARATION OF SEDATIVE AND ANESTHETIC MEDICAMENT | 四川海思科制药有限公司 | 2016-03-10 | — | — | WO | disclosed |
| WO-2016034079-A1 | USE OF GABAA RECEPTOR REINFORCING AGENT IN PREPARATION OF SEDATIVE AND ANESTHETIC MEDICAMENT | 四川海思科制药有限公司 | 2016-03-10 | — | — | WO | disclosed |
| CN-105384607-A | Isopropyl-phenol derivative and preparation method therefor | SICHUAN HAISCO PHARMACEUTICAL CO LTD | 2016-03-09 | — | — | CN | disclosed |
| CN-105384619-A | Isopropyl-phenol derivative and preparation method therefor | SICHUAN HAISCO PHARMACEUTICAL CO LTD | 2016-03-09 | — | — | CN | disclosed |
| US-20160060197-A1 | PHENOL DERIVATIVE AND PREPARATION METHOD AND USE IN MEDICINE THEREOF | SICHUAN HAISCO PHARMACEUTICAL CO., LTD. (CN) | 2016-03-03 | — | — | US | disclosed |
| US-20160060197-A1 | PHENOL DERIVATIVE AND PREPARATION METHOD AND USE IN MEDICINE THEREOF | SICHUAN HAISCO PHARMACEUTICAL CO., LTD. (CN) | 2016-03-03 | — | — | US | disclosed |
| US-20160060197-A1 | PHENOL DERIVATIVE AND PREPARATION METHOD AND USE IN MEDICINE THEREOF | SICHUAN HAISCO PHARMACEUTICAL CO., LTD. (CN) | 2016-03-03 | — | — | US | disclosed |
| CN-104507899-A | Phenol derivative, preparation method and medical application thereof | SICHUAN HAISCO PHARMACEUTICAL CO LTD | 2015-04-08 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10729666-B2 | Use of GABAA receptor reinforcing agent in preparation of sedative and anesthetic medicament | GABRA1, GABRA5, GABRA2 | GABRA1 1/4885GABRB2 9/4885CYP3A4 263/4885 |
| US-20160060197-A1 | PHENOL DERIVATIVE AND PREPARATION METHOD AND USE IN MEDICINE THEREOF | CYP2D6, CYP2B6, CYP2A6 | GABRA1 2665/4885GABRB2 3304/4885CYP3A4 24/4885 |
| US-20170290781-A1 | USE OF GABAA RECEPTOR REINFORCING AGENT IN PREPARATION OF SEDATIVE AND ANESTHETIC MEDICAMENT | GABRA1, GABRA5, GABRA2 | GABRA1 1/4885GABRB2 9/4885CYP3A4 263/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.