Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | HMGCR | P04035 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2007605 | 0.98 | TRPV1 (0.47) | TRPV1TAAR1TSHRMAPK1LMNA | |
| SCHEMBL10509984 | 0.86 | TAAR1 (0.62) | TRPV1TAAR1TSHRMAPK1LMNA | |
| SCHEMBL12629209 | 0.79 | TAAR1 (0.46) | TAAR1TSHRMAPK1LMNANFKB1 | |
| SCHEMBL2908281 | 0.79 | HMGCR (0.50) | TAAR1TSHRMAPK1LMNANFKB1 | |
| SCHEMBL13225464 | 0.78 | TAAR1 (0.50) | TRPV1TAAR1TSHRMAPK1LMNA | |
| SCHEMBL1754342 | 0.78 | TRPV1 (0.48) | TRPV1TAAR1TSHRMAPK1LMNA | |
| SCHEMBL12629556 | 0.78 | TRPV1 (0.48) | TRPV1TAAR1TSHRMAPK1LMNA | |
| SCHEMBL248581 | 0.78 | MAOB (0.48) | TRPV1TSHRLMNACYP3A4MEN1 | |
| SCHEMBL2729269 | 0.77 | GAA (0.53) | TRPV1TSHRLMNANFKB1CYP3A4 | |
| Hydrochloric Acid SCHEMBL2007942 | 0.76 | TRPV1 (0.47) | TRPV1TAAR1TSHRMAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8158650-B2 | Substituted phenylmethyl bicyclocarboxyamide compounds | PFIZER INC. (US) | 2012-04-17 | — | — | US | disclosed |
| US-8158650-B2 | Substituted phenylmethyl bicyclocarboxyamide compounds | PFIZER INC. (US) | 2012-04-17 | — | — | US | disclosed |
| US-8158650-B2 | Substituted phenylmethyl bicyclocarboxyamide compounds | PFIZER INC. (US) | 2012-04-17 | — | — | US | disclosed |
| EP-2222631-B1 | SUBSTITUTED PHENYLMETHYL BICYCLOCARBOXYAMIDE COMPOUNDS | PFIZER (US) | 2011-08-17 | — | — | EP | disclosed |
| EP-2222631-B1 | SUBSTITUTED PHENYLMETHYL BICYCLOCARBOXYAMIDE COMPOUNDS | PFIZER (US) | 2011-08-17 | — | — | EP | disclosed |
| US-7964642-B2 | Antiinflammatory agents, analgesics; 2-halo-4-hydroxy-5-methoxyphenyl-functional urea or thiourea compounds such as 1-(p-trifluoromethylbenzyl)-3-(2-iodo-4-hydroxy-5-methoxybenzyl)thiourea | PHARMESTE S.R.L. (IT) | 2011-06-21 | — | — | US | disclosed |
| EP-2222631-A2 | SUBSTITUTED PHENYLMETHYL BICYCLOCARBOXYAMIDE COMPOUNDS | Pfizer Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| US-20100087480-A1 | SUBSTITUTED PHENYLMETHYL BICYCLOCARBOXYAMIDE COMPOUNDS | PFIZER INC. | 2010-04-08 | — | — | US | disclosed |
| US-20100087480-A1 | SUBSTITUTED PHENYLMETHYL BICYCLOCARBOXYAMIDE COMPOUNDS | PFIZER INC. | 2010-04-08 | — | — | US | disclosed |
| US-20100087480-A1 | SUBSTITUTED PHENYLMETHYL BICYCLOCARBOXYAMIDE COMPOUNDS | PFIZER INC. | 2010-04-08 | — | — | US | disclosed |
| WO-2008050199-A2 | SUBSTITUTED PHENYLMETHYL BICYCLOCARBOXYAMIDE COMPOUNDS | PFIZER JAPAN INC. (JP) | 2008-05-02 | — | — | WO | disclosed |
| WO-2008050199-A2 | SUBSTITUTED PHENYLMETHYL BICYCLOCARBOXYAMIDE COMPOUNDS | PFIZER JAPAN INC. (JP) | 2008-05-02 | — | — | WO | disclosed |
| US-20080085936-A1 | Antiinflammatory agents, analgesics; 2-halo-4-hydroxy-5-methoxyphenyl-functional urea or thiourea compounds such as 1-(p-trifluoromethylbenzyl)-3-(2-iodo-4-hydroxy-5-methoxybenzyl)thiourea | PHARMESTE S.R.L. (IT) | 2008-04-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100087480-A1 | SUBSTITUTED PHENYLMETHYL BICYCLOCARBOXYAMIDE COMPOUNDS | TRPV1, P2RY1, TRPV2 | TRPV1 1/4885TAAR1 471/4885TSHR 3148/4885 |
| US-20080085936-A1 | Antiinflammatory agents, analgesics; 2-halo-4-hydroxy-5-methoxyphenyl-functional urea or thiourea compounds such as 1-(p-trifluoromethylbenzyl)-3-(2-iodo-4-hydroxy-5-methoxybenzyl)thiourea | SIGMAR1, PTGS1, TPMT | TRPV1 403/4885TAAR1 217/4885TSHR 737/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.