Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 12/20 | 0.67 |
| ▸ | NPC1 | O15118 | 11/20 | 0.67 |
| ▸ | MAPT | P10636 | 6/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.67 |
| ▸ | GAA | P10253 | 3/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.67 |
| ▸ | TP53 | P04637 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 12/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 12/20 | 0.63 |
| ▸ | CASP3 | P42574 | 2/20 | 0.63 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.63 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.63 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.63 |
| ▸ | PKM | P14618 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | VCP | P55072 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17539298 | 0.90 | RAB9A (0.66) | RAB9ANPC1MAPTSMN1; SMN2GAA | |
| SCHEMBL15587693 | 0.87 | RAB9A (0.62) | RAB9ANPC1MAPTSMN1; SMN2GAA | |
| SCHEMBL207261 | 0.86 | RAB9A (0.70) | RAB9ANPC1MAPTSMN1; SMN2GAA | |
| SCHEMBL19451091 | 0.86 | RAB9A (0.66) | RAB9ANPC1MAPTSMN1; SMN2GAA | |
| SCHEMBL15587795 | 0.83 | RAB9A (0.63) | RAB9ANPC1MAPTSMN1; SMN2GAA | |
| SCHEMBL206745 | 0.83 | MEN1 (0.70) | RAB9ANPC1MAPTSMN1; SMN2GAA | |
| SCHEMBL206589 | 0.81 | MEN1 (0.67) | RAB9ANPC1MAPTSMN1; SMN2GAA | |
| SCHEMBL12297416 | 0.81 | RAB9A (1.00) | RAB9ANPC1MAPTSMN1; SMN2GAA | |
| SCHEMBL205189 | 0.80 | MEN1 (0.66) | RAB9ANPC1MAPTSMN1; SMN2GAA | |
| SCHEMBL19102956 | 0.80 | RAB9A (0.58) | RAB9ANPC1MAPTSMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11564911-B2 | Small molecule dual-inhibitors of TRPV4 and TRPA1 for sanitizing and anesthetizing | DUKE UNIVERSITY (US) | 2023-01-31 | — | — | US | disclosed |
| US-11229628-B2 | TRPA1 and TRPV4 inhibitors and methods of using the same for organ-specific inflammation and itch | DUKE UNIVERSITY (US) | 2022-01-25 | — | — | US | disclosed |
| US-11014896-B2 | TRPA1 and TRPV4 inhibitors and methods of using the same for organ-specific inflammation and itch | DUKE UNIVERSITY (US) | 2021-05-25 | — | — | US | disclosed |
| US-20190315700-A1 | TRPA1 AND TRPV4 INHIBITORS AND METHODS OF USING THE SAME FOR ORGAN-SPECIFIC INFLAMMATION AND ITCH | DUKE UNIVERSITY | 2019-10-17 | — | — | US | disclosed |
| US-10329265-B2 | TRPA1 and TRPV4 inhibitors and methods of using the same for organ-specific inflammation and itch | DUKE UNIVERSITY (US) | 2019-06-25 | — | — | US | disclosed |
| US-20190091206-A1 | SMALL MOLECULE DUAL-INHIBITORS OF TRPV4 AND TRPA1 FOR SANITIZING AND ANESTHETIZING | DUKE UNIVERSITY | 2019-03-28 | — | — | US | disclosed |
| WO-2017177200-A1 | SMALL MOLECULE DUAL-INHIBITORS OF TRPV4 AND TRPA1 FOR SANITIZING AND ANESTHETIZING | DUKE UNIVERSITY (US) | 2017-10-12 | — | — | WO | disclosed |
| US-20170267651-A1 | TRPA1 AND TRPV4 INHIBITORS AND METHODS OF USING THE SAME FOR ORGAN-SPECIFIC INFLAMMATION AND ITCH | DUKE UNIVERSITY | 2017-09-21 | — | — | US | disclosed |
| US-20170267651-A1 | TRPA1 AND TRPV4 INHIBITORS AND METHODS OF USING THE SAME FOR ORGAN-SPECIFIC INFLAMMATION AND ITCH | DUKE UNIVERSITY | 2017-09-21 | — | — | US | disclosed |
| US-20160199363-A1 | TRPA1 AND TRPV4 INHIBITORS AND METHODS OF USING THE SAME FOR ORGAN-SPECIFIC INFLAMMATION AND ITCH | DUKE UNIVERSITY | 2016-07-14 | — | — | US | disclosed |
| US-20160199363-A1 | TRPA1 AND TRPV4 INHIBITORS AND METHODS OF USING THE SAME FOR ORGAN-SPECIFIC INFLAMMATION AND ITCH | DUKE UNIVERSITY | 2016-07-14 | — | — | US | disclosed |
| WO-2016028325-A1 | TRPA1 AND TRPV4 INHIBITORS AND METHODS OF USING THE SAME FOR ORGAN-SPECIFIC INFLAMMATION AND ITCH | DUKE UNIVERSITY (US) | 2016-02-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190315700-A1 | TRPA1 AND TRPV4 INHIBITORS AND METHODS OF USING THE SAME FOR ORGAN-SPECIFIC INFLAMMATION AND ITCH | TRPA1, TRPV4, TRPV2 | RAB9A 4469/4885NPC1 612/4885MAPT 1030/4885 |
| US-20160199363-A1 | TRPA1 AND TRPV4 INHIBITORS AND METHODS OF USING THE SAME FOR ORGAN-SPECIFIC INFLAMMATION AND ITCH | TRPA1, TRPV4, TRPV2 | RAB9A 4469/4885NPC1 612/4885MAPT 1030/4885 |
| US-20170267651-A1 | TRPA1 AND TRPV4 INHIBITORS AND METHODS OF USING THE SAME FOR ORGAN-SPECIFIC INFLAMMATION AND ITCH | TRPA1, TRPV4, TRPV2 | RAB9A 4469/4885NPC1 612/4885MAPT 1030/4885 |
| US-11229628-B2 | TRPA1 and TRPV4 inhibitors and methods of using the same for organ-specific inflammation and itch | TRPA1, TRPV4, TRPV2 | RAB9A 4469/4885NPC1 612/4885MAPT 1030/4885 |
| US-11564911-B2 | Small molecule dual-inhibitors of TRPV4 and TRPA1 for sanitizing and anesthetizing | TRPA1, TRPV4, TRPV1 | RAB9A 3733/4885NPC1 1817/4885MAPT 1870/4885 |
| US-10329265-B2 | TRPA1 and TRPV4 inhibitors and methods of using the same for organ-specific inflammation and itch | TRPA1, TRPV4, TRPV2 | RAB9A 4469/4885NPC1 612/4885MAPT 1030/4885 |
| US-20190091206-A1 | SMALL MOLECULE DUAL-INHIBITORS OF TRPV4 AND TRPA1 FOR SANITIZING AND ANESTHETIZING | TRPA1, TRPV4, TRPV1 | RAB9A 3733/4885NPC1 1817/4885MAPT 1870/4885 |
| US-11014896-B2 | TRPA1 and TRPV4 inhibitors and methods of using the same for organ-specific inflammation and itch | TRPA1, TRPV4, TRPV2 | RAB9A 4469/4885NPC1 612/4885MAPT 1030/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.