SCHEMBL1754055

SCHEMBL1754055

[CH2]c1[nH]nc(C(F)(F)F)c1Cc1ccc(OC)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
CYP2D6 P10635 1/20 0.42
ATM Q13315 1/20 0.42
LMNA P02545 1/20 0.42
KDM4E B2RXH2 2/20 0.42
MPI P34949 1/20 0.42
APOBEC3G Q9HC16 1/20 0.42
SLC5A2 P31639 1/20 0.41
POLB P06746 1/20 0.39
HPGD P15428 1/20 0.39
TSHR P16473 1/20 0.39
HSD17B10 Q99714 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
LTA4H P09960 1/20 0.39
FABP4 P15090 2/20 0.38
NPSR1 Q6W5P4 1/20 0.37
MEN1 O00255 1/20 0.37
KMT2A Q03164 1/20 0.37
ERAP1 Q9NZ08 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21994369 0.78 ALDH1A1 (0.40) ALDH1A1SMN1; SMN2CYP2D6ATMLMNA
SCHEMBL3633161 0.74 ALDH1A1 (0.50) ALDH1A1SMN1; SMN2CYP2D6ATMLMNA
SCHEMBL3468087 0.72 SLC5A2 (0.56) ALDH1A1SMN1; SMN2CYP2D6ATMLMNA
SCHEMBL21994450 0.70 GAA (0.42) ALDH1A1KDM4EMPIAPOBEC3GMEN1
SCHEMBL13274242 0.69 GAA (0.45) ALDH1A1SMN1; SMN2CYP2D6ATMLMNA
SCHEMBL9464633 0.67 LMNA (0.63) ALDH1A1SMN1; SMN2CYP2D6ATMLMNA
SCHEMBL2257910 0.66 ALDH1A1 (0.57) ALDH1A1SMN1; SMN2CYP2D6ATMLMNA
SCHEMBL20837142 0.65 MAPT (0.46) SMN1; SMN2KDM4EPOLBHPGDNPSR1
SCHEMBL21274894 0.65 ALDH1A1 (0.58) ALDH1A1SMN1; SMN2CYP2D6ATMLMNA
SCHEMBL1682189 0.65 SLC5A1 (0.53) ALDH1A1SMN1; SMN2CYP2D6ATMLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1966141-A1 SIX-MEMBERED HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS Brystol-Myers Squibb Company (US) 2008-09-10 EP claimed
WO-2007070818-A1 SIX-MEMBERED HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2007-06-21 WO claimed
EP-1981854-A1 ARYLPROPIONAMIDE, ARYLACRYLAMIDE, ARYLPROPYNAMIDE, OR ARYLMETHYLUREA ANALOGS AS FACTOR XIA INHIBITORS Brystol-Myers Squibb Company (US) 2008-10-22 EP disclosed
WO-2007070826-A1 ARYLPROPIONAMIDE, ARYLACRYLAMIDE, ARYLPROPYNAMIDE, OR ARYLMETHYLUREA ANALOGS AS FACTOR XIA INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2007-06-21 WO disclosed