Sugi Predict

Sugi Predict / Compounds / SCHEMBL17544110

SCHEMBL17544110

SCHEMBL17544110

O=C(Nc1ccc2oc(-c3cccnc3)nc2c1)C1Cc2ccccc2O1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 11/20 0.60
▸ HSD17B10 Q99714 7/20 0.60
▸ NPSR1 Q6W5P4 3/20 0.60
▸ RAB9A P51151 6/20 0.59
▸ NPC1 O15118 5/20 0.59
▸ ALDH1A1 P00352 12/20 0.58
▸ HPGD P15428 8/20 0.58
▸ POLB P06746 6/20 0.58
▸ USP2 O75604 2/20 0.58
▸ ESR1 P03372 1/20 0.58
▸ MAPT P10636 10/20 0.58
▸ L3MBTL1 Q9Y468 2/20 0.58
▸ PTK2B Q14289 1/20 0.58
▸ SMN1; SMN2 Q16637 4/20 0.57
▸ TP53 P04637 2/20 0.57
▸ KMT2A Q03164 2/20 0.56
▸ PTPN7 P35236 1/20 0.56
▸ PPARG P37231 1/20 0.56
▸ DUSP3 P51452 1/20 0.56
▸ NR2E3 Q9Y5X4 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29681121 1.00 KDM4E (0.60) KDM4EHSD17B10NPSR1RAB9ANPC1
SCHEMBL29000625 0.78 KDM4E (0.77) KDM4EHSD17B10NPSR1RAB9ANPC1
SCHEMBL19307174 0.78 ALDH1A1 (0.63) KDM4EHSD17B10NPSR1RAB9ANPC1
SCHEMBL24449110 0.78 ALDH1A1 (0.63) KDM4EHSD17B10NPSR1RAB9ANPC1
SCHEMBL29614895 0.78 ALDH1A1 (0.63) KDM4EHSD17B10NPSR1RAB9ANPC1
SCHEMBL19307177 0.77 ALDH1A1 (0.74) KDM4EHSD17B10NPSR1RAB9ANPC1
SCHEMBL16933404 0.77 ROCK2 (0.67) KDM4EHSD17B10NPSR1RAB9ANPC1
SCHEMBL2248127 0.76 KDM4E (0.89) KDM4EHSD17B10NPSR1RAB9ANPC1
SCHEMBL16939826 0.76 ALDH1A1 (0.61) KDM4EHSD17B10NPSR1RAB9ANPC1
SCHEMBL15597509 0.75 ALDH1A1 (0.57) KDM4EHSD17B10NPSR1RAB9ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200102328-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN EVOTEC (UK) LTD. (GB) 2020-04-02 — — US claimed
US-10479802-B2 Probes for imaging huntingtin protein CHDI FOUNDATION, INC. (US) 2019-11-19 — — US claimed
US-20170283436-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN EVOTEC (UK) LTD. (GB) 2017-10-05 — — US claimed
EP-3186233-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI Foundation, Inc. (US) 2017-07-05 — — EP claimed
WO-2016033445-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. (US) 2016-03-03 — — WO claimed
US-12258355-B2 Probes for imaging huntingtin protein CHDI FOUNDATION, INC. (US) 2025-03-25 — — US disclosed
US-12083108-B2 Compounds for targeting mutant huntingtin protein and uses thereof CHDI FOUNDATION, INC. (US) 2024-09-10 — — US disclosed
CN-116655618-A Probes for imaging huntingtin CHDI基金会股份有限公司 2023-08-29 — — CN disclosed
US-20230212190-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2023-07-06 — — US disclosed
US-20230212190-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2023-07-06 — — US disclosed
US-20230212190-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2023-07-06 — — US disclosed
CN-107108534-B Probes for imaging huntingtin CHDI基金会股份有限公司 2023-05-09 — — CN disclosed
US-20200102328-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN EVOTEC (UK) LTD. (GB) 2020-04-02 — — US disclosed
US-10479802-B2 Probes for imaging huntingtin protein CHDI FOUNDATION, INC. (US) 2019-11-19 — — US disclosed
US-10479802-B2 Probes for imaging huntingtin protein CHDI FOUNDATION, INC. (US) 2019-11-19 — — US disclosed
US-20170283436-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN EVOTEC (UK) LTD. (GB) 2017-10-05 — — US disclosed
US-20170283436-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN EVOTEC (UK) LTD. (GB) 2017-10-05 — — US disclosed
US-20170283436-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN EVOTEC (UK) LTD. (GB) 2017-10-05 — — US disclosed
EP-3186233-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI Foundation, Inc. (US) 2017-07-05 — — EP disclosed
WO-2016033445-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. (US) 2016-03-03 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230212190-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN HTT, HYPK, HSPBP1 KDM4E 4585/4885HSD17B10 966/4885NPSR1 885/4885
US-12083108-B2 Compounds for targeting mutant huntingtin protein and uses thereof HTT, HYPK, UBQLN2 KDM4E 2698/4885HSD17B10 2464/4885NPSR1 4163/4885
US-10479802-B2 Probes for imaging huntingtin protein HTT, HYPK, FABP7 KDM4E 4674/4885HSD17B10 883/4885NPSR1 818/4885
US-20200102328-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN HTT, HYPK, HSPBP1 KDM4E 4585/4885HSD17B10 966/4885NPSR1 885/4885
US-20170283436-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN HTT, HYPK, FABP7 KDM4E 4674/4885HSD17B10 883/4885NPSR1 818/4885
US-12258355-B2 Probes for imaging huntingtin protein HTT, HYPK, HSPBP1 KDM4E 4585/4885HSD17B10 966/4885NPSR1 885/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.