Sugi Predict

Sugi Predict / Compounds / SCHEMBL17544253

SCHEMBL17544253

SCHEMBL17544253

COc1ccc(COc2ccc3oc(-c4cccc(C#N)c4)nc3c2)nc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TP53 P04637 5/20 0.50
▸ RXFP1 Q9HBX9 1/20 0.50
▸ ALDH1A1 P00352 8/20 0.47
▸ HPGD P15428 5/20 0.47
▸ HSD17B10 Q99714 5/20 0.47
▸ RAB9A P51151 4/20 0.47
▸ SMN1; SMN2 Q16637 4/20 0.47
▸ KDM4E B2RXH2 3/20 0.47
▸ NPC1 O15118 3/20 0.47
▸ NFKB1 P19838 2/20 0.47
▸ NFKB2 Q00653 2/20 0.47
▸ RELA Q04206 2/20 0.47
▸ L3MBTL1 Q9Y468 2/20 0.47
▸ GLA P06280 2/20 0.47
▸ TDP1 Q9NUW8 1/20 0.47
▸ HPSE Q9Y251 1/20 0.46
▸ TSHR P16473 4/20 0.44
▸ MAPK1 P28482 2/20 0.44
▸ MAPT P10636 2/20 0.44
▸ CASP3 P42574 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30402927 1.00 TP53 (0.50) TP53RXFP1ALDH1A1HPGDHSD17B10
SCHEMBL17544504 0.89 PDE10A (0.52) TP53RXFP1ALDH1A1RAB9ASMN1; SMN2
SCHEMBL30403115 0.89 PDE10A (0.52) TP53RXFP1ALDH1A1RAB9ASMN1; SMN2
SCHEMBL23633322 0.86 SMN1; SMN2 (0.58) TP53RXFP1ALDH1A1HPGDHSD17B10
SCHEMBL17544004 0.85 ALDH1A1 (0.49) TP53ALDH1A1HPGDHSD17B10RAB9A
SCHEMBL19428553 0.85 ALDH1A1 (0.49) TP53ALDH1A1HPGDHSD17B10RAB9A
SCHEMBL17544014 0.84 ALDH1A1 (0.46) TP53RXFP1ALDH1A1HPGDHSD17B10
SCHEMBL29680869 0.84 ALDH1A1 (0.46) TP53RXFP1ALDH1A1HPGDHSD17B10
SCHEMBL17544578 0.83 ALDH1A1 (0.53) TP53ALDH1A1HPGDHSD17B10RAB9A
SCHEMBL17544797 0.83 HSD17B10 (0.53) TP53ALDH1A1HPGDHSD17B10RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200102328-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN EVOTEC (UK) LTD. (GB) 2020-04-02 — — US claimed
US-10479802-B2 Probes for imaging huntingtin protein CHDI FOUNDATION, INC. (US) 2019-11-19 — — US claimed
US-20170283436-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN EVOTEC (UK) LTD. (GB) 2017-10-05 — — US claimed
EP-3186233-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI Foundation, Inc. (US) 2017-07-05 — — EP claimed
WO-2016033445-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. (US) 2016-03-03 — — WO claimed
US-12258355-B2 Probes for imaging huntingtin protein CHDI FOUNDATION, INC. (US) 2025-03-25 — — US disclosed
US-12083108-B2 Compounds for targeting mutant huntingtin protein and uses thereof CHDI FOUNDATION, INC. (US) 2024-09-10 — — US disclosed
CN-116655618-A Probes for imaging huntingtin CHDI基金会股份有限公司 2023-08-29 — — CN disclosed
US-20230212190-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2023-07-06 — — US disclosed
US-20230212190-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2023-07-06 — — US disclosed
US-20230212190-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2023-07-06 — — US disclosed
CN-107108534-B Probes for imaging huntingtin CHDI基金会股份有限公司 2023-05-09 — — CN disclosed
US-10479802-B2 Probes for imaging huntingtin protein CHDI FOUNDATION, INC. (US) 2019-11-19 — — US disclosed
US-10479802-B2 Probes for imaging huntingtin protein CHDI FOUNDATION, INC. (US) 2019-11-19 — — US disclosed
US-20170283436-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN EVOTEC (UK) LTD. (GB) 2017-10-05 — — US disclosed
US-20170283436-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN EVOTEC (UK) LTD. (GB) 2017-10-05 — — US disclosed
US-20170283436-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN EVOTEC (UK) LTD. (GB) 2017-10-05 — — US disclosed
EP-3186233-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI Foundation, Inc. (US) 2017-07-05 — — EP disclosed
WO-2016033445-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. (US) 2016-03-03 — — WO disclosed
WO-2016033445-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. (US) 2016-03-03 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230212190-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN HTT, HYPK, HSPBP1 TP53 741/4885RXFP1 660/4885ALDH1A1 3976/4885
US-12083108-B2 Compounds for targeting mutant huntingtin protein and uses thereof HTT, HYPK, UBQLN2 TP53 42/4885RXFP1 4566/4885ALDH1A1 3950/4885
US-10479802-B2 Probes for imaging huntingtin protein HTT, HYPK, FABP7 TP53 743/4885RXFP1 725/4885ALDH1A1 3949/4885
US-20200102328-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN HTT, HYPK, HSPBP1 TP53 741/4885RXFP1 660/4885ALDH1A1 3976/4885
US-20170283436-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN HTT, HYPK, FABP7 TP53 743/4885RXFP1 725/4885ALDH1A1 3949/4885
US-12258355-B2 Probes for imaging huntingtin protein HTT, HYPK, HSPBP1 TP53 741/4885RXFP1 660/4885ALDH1A1 3976/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.