Sugi Predict

Sugi Predict / Compounds / SCHEMBL17544366

SCHEMBL17544366

SCHEMBL17544366

O=C(Cc1ccc2oc(-c3cccnc3)nc2c1)c1ccccn1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 13/20 0.71
▸ ALDH1A1 P00352 10/20 0.69
▸ NPC1 O15118 6/20 0.69
▸ MAPK1 P28482 2/20 0.69
▸ TSHR P16473 2/20 0.63
▸ HSD17B10 Q99714 7/20 0.57
▸ HPGD P15428 6/20 0.57
▸ POLB P06746 4/20 0.57
▸ USP2 O75604 2/20 0.57
▸ ESR1 P03372 1/20 0.57
▸ MAPT P10636 6/20 0.53
▸ TP53 P04637 3/20 0.53
▸ RAB9A P51151 6/20 0.53
▸ NPSR1 Q6W5P4 4/20 0.52
▸ CYP1A2 P05177 1/20 0.52
▸ CYP2C19 P33261 1/20 0.52
▸ HTT P42858 1/20 0.52
▸ PTK2B Q14289 1/20 0.52
▸ L3MBTL1 Q9Y468 1/20 0.52
▸ MEN1 O00255 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29681116 1.00 KDM4E (0.71) KDM4EALDH1A1NPC1MAPK1TSHR
SCHEMBL17553652 0.92 KDM4E (0.59) KDM4EALDH1A1NPC1MAPK1TSHR
SCHEMBL19428488 0.86 KDM4E (0.79) KDM4EALDH1A1NPC1MAPK1TSHR
SCHEMBL25795646 0.83 KDM4E (1.00) KDM4EALDH1A1NPC1MAPK1TSHR
SCHEMBL30401752 0.78 TSHR (0.80) KDM4EALDH1A1NPC1MAPK1TSHR
SCHEMBL17541563 0.78 TSHR (0.80) KDM4EALDH1A1NPC1MAPK1TSHR
SCHEMBL17544222 0.78 TSHR (0.64) KDM4EALDH1A1NPC1MAPK1TSHR
SCHEMBL30402997 0.78 TSHR (0.64) KDM4EALDH1A1NPC1MAPK1TSHR
SCHEMBL24449082 0.78 KDM4E (0.72) KDM4EALDH1A1NPC1MAPK1TSHR
SCHEMBL23633316 0.76 KDM4E (0.74) KDM4EALDH1A1NPC1MAPK1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200102328-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN EVOTEC (UK) LTD. (GB) 2020-04-02 — — US claimed
US-10479802-B2 Probes for imaging huntingtin protein CHDI FOUNDATION, INC. (US) 2019-11-19 — — US claimed
US-20170283436-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN EVOTEC (UK) LTD. (GB) 2017-10-05 — — US claimed
EP-3186233-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI Foundation, Inc. (US) 2017-07-05 — — EP claimed
WO-2016033445-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. (US) 2016-03-03 — — WO claimed
US-12258355-B2 Probes for imaging huntingtin protein CHDI FOUNDATION, INC. (US) 2025-03-25 — — US disclosed
US-12083108-B2 Compounds for targeting mutant huntingtin protein and uses thereof CHDI FOUNDATION, INC. (US) 2024-09-10 — — US disclosed
CN-116655618-A Probes for imaging huntingtin CHDI基金会股份有限公司 2023-08-29 — — CN disclosed
US-20230212190-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2023-07-06 — — US disclosed
US-20230212190-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2023-07-06 — — US disclosed
US-20230212190-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2023-07-06 — — US disclosed
CN-107108534-B Probes for imaging huntingtin CHDI基金会股份有限公司 2023-05-09 — — CN disclosed
US-20200102328-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN EVOTEC (UK) LTD. (GB) 2020-04-02 — — US disclosed
US-10479802-B2 Probes for imaging huntingtin protein CHDI FOUNDATION, INC. (US) 2019-11-19 — — US disclosed
US-10479802-B2 Probes for imaging huntingtin protein CHDI FOUNDATION, INC. (US) 2019-11-19 — — US disclosed
US-20170283436-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN EVOTEC (UK) LTD. (GB) 2017-10-05 — — US disclosed
US-20170283436-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN EVOTEC (UK) LTD. (GB) 2017-10-05 — — US disclosed
US-20170283436-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN EVOTEC (UK) LTD. (GB) 2017-10-05 — — US disclosed
EP-3186233-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI Foundation, Inc. (US) 2017-07-05 — — EP disclosed
WO-2016033445-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. (US) 2016-03-03 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230212190-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN HTT, HYPK, HSPBP1 KDM4E 4585/4885ALDH1A1 3976/4885NPC1 163/4885
US-12083108-B2 Compounds for targeting mutant huntingtin protein and uses thereof HTT, HYPK, UBQLN2 KDM4E 2698/4885ALDH1A1 3950/4885NPC1 1066/4885
US-10479802-B2 Probes for imaging huntingtin protein HTT, HYPK, FABP7 KDM4E 4674/4885ALDH1A1 3949/4885NPC1 112/4885
US-20200102328-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN HTT, HYPK, HSPBP1 KDM4E 4585/4885ALDH1A1 3976/4885NPC1 163/4885
US-20170283436-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN HTT, HYPK, FABP7 KDM4E 4674/4885ALDH1A1 3949/4885NPC1 112/4885
US-12258355-B2 Probes for imaging huntingtin protein HTT, HYPK, HSPBP1 KDM4E 4585/4885ALDH1A1 3976/4885NPC1 163/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.