Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.61 |
| ▸ | ACHE | P22303 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 6/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | GNE | Q9Y223 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | TRPC3 | Q13507 | 3/20 | 0.46 |
| ▸ | TRPC6 | Q9Y210 | 3/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13450099 | 0.85 | HSD11B1 (0.61) | HSD11B1ACHEHPGDALDH1A1NPC1 | |
| SCHEMBL20006775 | 0.84 | GNE (0.46) | HSD11B1ACHEHPGDALDH1A1NPC1 | |
| SCHEMBL13450575 | 0.84 | HSD11B1 (0.60) | HSD11B1ACHEHPGDALDH1A1NPC1 | |
| SCHEMBL12751750 | 0.84 | HSD11B1 (0.67) | HSD11B1ACHEHPGDALDH1A1NPC1 | |
| SCHEMBL2590496 | 0.84 | HSD11B1 (0.60) | HSD11B1ACHEHPGDALDH1A1NPC1 | |
| SCHEMBL2593742 | 0.82 | HSD11B1 (0.58) | HSD11B1ACHEHPGDALDH1A1NPC1 | |
| SCHEMBL12753656 | 0.80 | HSD11B1 (0.70) | HSD11B1ACHEHPGDALDH1A1NPC1 | |
| SCHEMBL2591255 | 0.79 | HSD11B1 (0.56) | HSD11B1ACHEHPGDALDH1A1NPC1 | |
| SCHEMBL12753393 | 0.78 | HSD11B1 (0.63) | HSD11B1ACHEHPGDALDH1A1NPC1 | |
| SCHEMBL12753329 | 0.78 | HSD11B1 (0.63) | HSD11B1ACHEHPGDALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190144429-A1 | RORC2 INHIBITORS AND METHODS OF USE THEREOF | PFIZER INC. (US) | 2019-05-16 | — | — | US | disclosed |
| EP-3428160-A1 | HETEROBICYCLOARYL RORC2 INHIBITORS AND METHODS OF USE THEREOF | Pfizer Inc (US) | 2019-01-16 | — | — | EP | disclosed |
| US-20170233371-A1 | RORC2 INHIBITORS AND METHODS OF USE THEREOF | PFIZER INC. (US) | 2017-08-17 | — | — | US | disclosed |
| US-20160046597-A1 | RORC2 INHIBITORS AND METHODS OF USE THEREOF | PFIZER (US) | 2016-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160046597-A1 | RORC2 INHIBITORS AND METHODS OF USE THEREOF | RORC, RORB, RORA | HSD11B1 52/4885ACHE 4376/4885HPGD 1088/4885 |
| US-20170233371-A1 | RORC2 INHIBITORS AND METHODS OF USE THEREOF | RORC, RORB, RORA | HSD11B1 52/4885ACHE 4376/4885HPGD 1088/4885 |
| US-20190144429-A1 | RORC2 INHIBITORS AND METHODS OF USE THEREOF | RORC, RORB, RORA | HSD11B1 52/4885ACHE 4376/4885HPGD 1088/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.