Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 1/20 | 0.69 |
| ▸ | HTT | P42858 | 3/20 | 0.65 |
| ▸ | TSHR | P16473 | 2/20 | 0.65 |
| ▸ | HPGD | P15428 | 2/20 | 0.65 |
| ▸ | NPC1 | O15118 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.65 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.65 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.58 |
| ▸ | NAMPT | P43490 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | ESRRG | P62508 | 1/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MPO | P05164 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1754811 | 0.90 | NAAA (0.64) | NAAAHTTTSHRHPGDNPC1 | |
| Hydrochloric Acid SCHEMBL15769552 | 0.90 | HTT (0.73) | NAAAHTTTSHRHPGDNPC1 | |
| SCHEMBL15985328 | 0.89 | ALOX5 (0.76) | NAAAHTTTSHRHPGDNPC1 | |
| SCHEMBL823552 | 0.86 | NAAA (0.84) | NAAAHTTTSHRHPGDNPC1 | |
| SCHEMBL15985188 | 0.85 | ALOX5 (0.81) | NAAAHTTTSHRHPGDNPC1 | |
| SCHEMBL16792228 | 0.85 | TSHR (0.63) | NAAAHTTTSHRHPGDNPC1 | |
| SCHEMBL3148607 | 0.85 | NAAA (0.88) | NAAAHTTTSHRHPGDNPC1 | |
| SCHEMBL15985307 | 0.84 | ALOX5 (0.84) | NAAAHTTTSHRHPGDNPC1 | |
| SCHEMBL5707054 | 0.84 | HTT (0.69) | NAAAHTTTSHRHPGDNPC1 | |
| SCHEMBL31119120 | 0.84 | HTT (0.69) | NAAAHTTTSHRHPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8158783-B2 | MTP inhibiting tetrahydro-naphthalene-1-carboxylic acid derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2012-04-17 | — | — | US | disclosed |
| US-20100016291-A1 | MTP INHIBITING TETRAHYDRO-NAPHTHALENE-1-CARBOXYLIC ACID DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100016291-A1 | MTP INHIBITING TETRAHYDRO-NAPHTHALENE-1-CARBOXYLIC ACID DERIVATIVES | PNLIP, APOB, MTPN | NAAA 544/4885HTT 477/4885TSHR 2141/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.