Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6382915 | 0.80 | TDP1 (0.43) | ALDH1A1HPGDCYP1A2HSD17B10TDP1 | |
| SCHEMBL10534182 | 0.78 | CYP1A2 (0.42) | ALDH1A1HPGDCYP1A2HSD17B10TDP1 | |
| SCHEMBL6377841 | 0.75 | TDP1 (0.40) | ALDH1A1HPGDCYP1A2HSD17B10TDP1 | |
| SCHEMBL8985754 | 0.75 | GABRA1 (0.36) | ALDH1A1KDM4EMEN1KMT2AL3MBTL1 | |
| SCHEMBL5899067 | 0.74 | CYP1A2 (0.44) | ALDH1A1HPGDCYP1A2HSD17B10TDP1 | |
| SCHEMBL153241 | 0.72 | CYP1A2 (0.46) | ALDH1A1HPGDCYP1A2HSD17B10TDP1 | |
| SCHEMBL2915678 | 0.72 | CYP1A2 (0.46) | ALDH1A1HPGDCYP1A2HSD17B10TDP1 | |
| SCHEMBL8801626 | 0.72 | ALDH1A1 (0.36) | ALDH1A1TDP1KDM4EMEN1KMT2A | |
| SCHEMBL9683061 | 0.71 | ALDH1A1 (0.58) | ALDH1A1CYP1A2HSD17B10CYP3A4MAOA | |
| SCHEMBL14394617 | 0.69 | L3MBTL1 (0.45) | ALDH1A1HPGDCYP1A2HSD17B10TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833816-B1 | SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2009-11-11 | — | — | EP | claimed |
| EP-2054407-A2 | PYROLIDINE DERIVATIVES USEFUL AGAINST DISEASES THAT DEPENDS ON ACTIVITY OF RENIN | Novartis AG (CH) | 2009-05-06 | — | — | EP | claimed |
| EP-2032530-A1 | PYRROLIDINE COMPOUNDS AS RENIN INHIBITORS | Novartis AG (CH) | 2009-03-11 | — | — | EP | claimed |
| EP-2029544-A1 | PYRROLIDINE DERIVATIVES USEFUL AS BACE INHIBITORS | Novartis AG (CH) | 2009-03-04 | — | — | EP | claimed |
| EP-1907359-A2 | 3,5-SUBSTITUTED PIPERIDINE DERIVATIVES EFFECTIVE ON RENIN-RELATED DISORDERS | Novartis AG (CH) | 2008-04-09 | — | — | EP | claimed |
| WO-2007144129-A2 | PYRROLIDINE DERIVATIVES USEFUL AGAINST DISEASES THAT DEPENDS ON ACTIVITY OF RENIN | NOVARTIS AG (CH) | 2007-12-21 | — | — | WO | claimed |
| WO-2007144128-A1 | PYRROLIDINE COMPOUNDS AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2007-12-21 | — | — | WO | claimed |
| WO-2007140980-A1 | PYRROLIDINE DERIVATIVES USEFUL AS BACE INHIBITORS | NOVARTIS AG (CH) | 2007-12-13 | — | — | WO | claimed |
| WO-2007006534-A2 | PIPERIDINE DERIVATIVES USEFUL IN THE DIAGNOSTIC AND THERAPEUTIC TREATMENT OF DISEASES DEPENDING ON RENIN ACTIVITY | NOVARTIS AG (CH) | 2007-01-18 | — | — | WO | claimed |
| EP-2142535-A2 | 3-IMIDAZOLYL-INDOLES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | Novartis Ag (CH) | 2010-01-13 | — | — | EP | disclosed |
| EP-2079744-A1 | IMIDAZOPYRIDAZINES AS PI3K LIPID KINASE INHIBITORS | Novartis AG (CH) | 2009-07-22 | — | — | EP | disclosed |
| EP-2054407-A2 | PYROLIDINE DERIVATIVES USEFUL AGAINST DISEASES THAT DEPENDS ON ACTIVITY OF RENIN | Novartis AG (CH) | 2009-05-06 | — | — | EP | disclosed |
| EP-2032530-A1 | PYRROLIDINE COMPOUNDS AS RENIN INHIBITORS | Novartis AG (CH) | 2009-03-11 | — | — | EP | disclosed |
| WO-2008119741-A2 | 3-IMIDAZOLYL-INDOLES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | NOVARTIS AG (CH) | 2008-10-09 | — | — | WO | disclosed |
| WO-2008052733-A1 | IMIDAZOPYRIDAZINES AS PI3K LIPID KINASE INHIBITORS | NOVARTIS AG (CH) | 2008-05-08 | — | — | WO | disclosed |
| WO-2007144129-A2 | PYRROLIDINE DERIVATIVES USEFUL AGAINST DISEASES THAT DEPENDS ON ACTIVITY OF RENIN | NOVARTIS AG (CH) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007144128-A1 | PYRROLIDINE COMPOUNDS AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2007-12-21 | — | — | WO | disclosed |
| EP-1836163-A2 | PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF A DISEASE DEPENDING ON THE ACTIVITY OF RENIN | Novartis AG (CH) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006066896-A2 | PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF A DISEASE DEPENDING ON THE ACTIVITY OF RENIN | NOVARTIS AG (CH) | 2006-06-29 | — | — | WO | disclosed |