Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | CTSD | P07339 | 3/20 | 0.41 |
| ▸ | NOS3 | P29474 | 2/20 | 0.39 |
| ▸ | NOS1 | P29475 | 2/20 | 0.39 |
| ▸ | NOS2 | P35228 | 2/20 | 0.39 |
| ▸ | BCHE | P06276 | 3/20 | 0.38 |
| ▸ | ACHE | P22303 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | CCR3 | P51677 | 1/20 | 0.33 |
| ▸ | ACE | P12821 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10047205 | 0.83 | KMT2A (0.43) | SIGMAR1CTSDNOS3NOS1NOS2 | |
| SCHEMBL15090847 | 0.82 | SIGMAR1 (0.41) | SIGMAR1CTSDNOS3NOS1NOS2 | |
| SCHEMBL2090957 | 0.82 | SIGMAR1 (0.41) | SIGMAR1CTSDNOS3NOS1NOS2 | |
| SCHEMBL15090906 | 0.80 | SIGMAR1 (0.40) | SIGMAR1CTSDNOS3NOS1NOS2 | |
| SCHEMBL15090844 | 0.79 | SIGMAR1 (0.39) | SIGMAR1CTSDNOS3NOS1NOS2 | |
| SCHEMBL1754869 | 0.77 | NOS1 (0.51) | SIGMAR1NOS3NOS1NOS2NOTUM | |
| SCHEMBL1754212 | 0.71 | SIGMAR1 (0.50) | SIGMAR1CTSDNOS3NOS1NOS2 | |
| SCHEMBL15355395 | 0.67 | OPRM1 (0.49) | ALDH1A1LMNANOTUMACE | |
| SCHEMBL15090871 | 0.65 | SIGMAR1 (0.40) | SIGMAR1CTSDNOS3NOS1NOS2 | |
| SCHEMBL10615392 | 0.65 | SIGMAR1 (0.54) | SIGMAR1CTSDNOS3NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8673898-B2 | Aminodiazepines as toll-like receptor modulators | ARRAY BIOPHARMA INC. (US) | 2014-03-18 | — | — | US | claimed |
| EP-1928845-B1 | Aminodiazepines as toll-like receptor modulators | ARRAY BIOPHARMA INC (US) | 2013-07-10 | — | — | EP | claimed |
| US-20120208801-A1 | Aminodiazepines as Toll-Like Receptor Modulators | ARRAY BIOPHARMA INC. (US) | 2012-08-16 | — | — | US | claimed |
| US-8163738-B2 | Aminodiazepines as toll-like receptor modulators | ARRAY BIOPHARMA INC. (US) | 2012-04-24 | — | — | US | claimed |
| US-20080306050-A1 | Aminodiazepines as Toll-Like Receptor Modulators | ARRAY BIOPHARMA INC. (CO) | 2008-12-11 | — | — | US | claimed |
| EP-1928845-A2 | AMINODIAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS | Array Biopharma, Inc. (US) | 2008-06-11 | — | — | EP | claimed |
| WO-2007040840-A2 | AMINODIAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS | ARRAY BIOPHARMA INC. (US) | 2007-04-12 | — | — | WO | claimed |
| US-8673898-B2 | Aminodiazepines as toll-like receptor modulators | ARRAY BIOPHARMA INC. (US) | 2014-03-18 | — | — | US | disclosed |
| EP-1928845-B1 | Aminodiazepines as toll-like receptor modulators | ARRAY BIOPHARMA INC (US) | 2013-07-10 | — | — | EP | disclosed |
| US-20120208801-A1 | Aminodiazepines as Toll-Like Receptor Modulators | ARRAY BIOPHARMA INC. (US) | 2012-08-16 | — | — | US | disclosed |
| US-8163738-B2 | Aminodiazepines as toll-like receptor modulators | ARRAY BIOPHARMA INC. (US) | 2012-04-24 | — | — | US | disclosed |
| US-20080306050-A1 | Aminodiazepines as Toll-Like Receptor Modulators | ARRAY BIOPHARMA INC. (CO) | 2008-12-11 | — | — | US | disclosed |
| EP-1928845-A2 | AMINODIAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS | Array Biopharma, Inc. (US) | 2008-06-11 | — | — | EP | disclosed |
| WO-2007040840-A2 | AMINODIAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS | ARRAY BIOPHARMA INC. (US) | 2007-04-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120208801-A1 | Aminodiazepines as Toll-Like Receptor Modulators | TLR8, TLR1, TLR5 | SIGMAR1 404/4885CTSD 2484/4885NOS3 1265/4885 |
| US-20080306050-A1 | Aminodiazepines as Toll-Like Receptor Modulators | TLR8, TLR1, TLR5 | SIGMAR1 404/4885CTSD 2484/4885NOS3 1265/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.