Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 4/20 | 0.49 |
| ▸ | DDO | Q99489 | 2/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | MGAM | O43451 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SI | P14410 | 1/20 | 0.32 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2729184 | 0.75 | DAO (0.50) | DAODDOCA12CA9HRH4 | |
| SCHEMBL29369387 | 0.72 | DAO (0.46) | DAODDOCA12CA9HRH4 | |
| SCHEMBL4196645 | 0.70 | DAO (0.71) | DAODDOCA12CA9HRH4 | |
| SCHEMBL2717082 | 0.70 | MGAM (0.32) | MGAMGAASIMGAM2 | |
| SCHEMBL17549873 | 0.70 | ATM (0.31) | MGAMGAASIMGAM2 | |
| SCHEMBL17549519 | 0.70 | MGAM (0.33) | MGAMGAASIMGAM2 | |
| SCHEMBL12970395 | 0.70 | DAO (0.65) | DAODDOCA12CA9HRH4 | |
| SCHEMBL25006241 | 0.68 | KDM4E (0.32) | — | |
| SCHEMBL28779468 | 0.68 | NPC1 (0.41) | MGAMGAASIMGAM2 | |
| SCHEMBL22011577 | 0.67 | ALDH1A1 (0.54) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445900-B1 | POLYCYCLIC DERIVATIVES OF PYRIDINE AND THEIR USE IN THE TREATMENT OF (INTER ALIA) RHEUMATOID ARTHRITIS AND SIMILAR DISEASES | AMGEN INC (US) | 2016-03-02 | — | — | EP | disclosed |