Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | MGAM | O43451 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | SI | P14410 | 1/20 | 0.30 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2717082 | 0.81 | MGAM (0.32) | ATMMGAMGAASIMGAM2 | |
| SCHEMBL17549519 | 0.78 | MGAM (0.33) | MGAMGAASIMGAM2 | |
| SCHEMBL2719477 | 0.77 | PIK3CD (0.42) | ATM | |
| SCHEMBL17549522 | 0.70 | DAO (0.49) | MGAMGAASIMGAM2 | |
| SCHEMBL25006241 | 0.67 | KDM4E (0.32) | — | |
| SCHEMBL28779468 | 0.67 | NPC1 (0.41) | MGAMGAASIMGAM2 | |
| SCHEMBL19787851 | 0.67 | MEN1 (0.33) | — | |
| SCHEMBL2717531 | 0.66 | PIK3CD (0.42) | ATM | |
| SCHEMBL22011577 | 0.66 | ALDH1A1 (0.54) | ATM | |
| SCHEMBL28779470 | 0.66 | ALDH1A1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445900-B1 | POLYCYCLIC DERIVATIVES OF PYRIDINE AND THEIR USE IN THE TREATMENT OF (INTER ALIA) RHEUMATOID ARTHRITIS AND SIMILAR DISEASES | AMGEN INC (US) | 2016-03-02 | — | — | EP | disclosed |