Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2717082 | 0.85 | MGAM (0.32) | MEN1NPC1RAB9AKMT2A | |
| SCHEMBL19787865 | 0.75 | ALOX5AP (0.44) | MEN1KMT2A | |
| SCHEMBL25006606 | 0.68 | ALDH1A1 (0.35) | MEN1NPC1RAB9AKMT2A | |
| SCHEMBL25006241 | 0.68 | KDM4E (0.32) | — | |
| SCHEMBL17549873 | 0.67 | ATM (0.31) | — | |
| SCHEMBL17549519 | 0.67 | MGAM (0.33) | — | |
| SCHEMBL2209672 | 0.63 | NPC1 (0.38) | NPC1RAB9A | |
| SCHEMBL22509683 | 0.62 | BACE1 (0.48) | NPC1RAB9A | |
| SCHEMBL514390 | 0.62 | ACHE (0.42) | — | |
| SCHEMBL28779468 | 0.62 | NPC1 (0.41) | NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9873704-B2 | Heterocyclic compounds and their uses | AMGEN INC. (US) | 2018-01-23 | — | — | US | disclosed |