SCHEMBL17552176

SCHEMBL17552176

Cc1ccc2cccc(NC(=O)c3cc4ccccc4s3)c2n1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.59
GAA P10253 1/20 0.59
DHPS P49366 1/20 0.55
ALDH1A1 P00352 2/20 0.53
TSHR P16473 1/20 0.53
HSD17B10 Q99714 1/20 0.53
MEN1 O00255 1/20 0.53
ALOX12 P18054 1/20 0.53
KMT2A Q03164 1/20 0.53
TP53 P04637 3/20 0.53
TMIGD3 P0DMS9 2/20 0.53
ADORA1 P30542 2/20 0.53
HDAC1 Q13547 2/20 0.52
HDAC3 O15379 1/20 0.52
HDAC4 P56524 1/20 0.52
HDAC7 Q8WUI4 1/20 0.52
HDAC2 Q92769 1/20 0.52
HDAC10 Q969S8 1/20 0.52
HDAC11 Q96DB2 1/20 0.52
HDAC8 Q9BY41 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19422877 0.84 DHPS (0.54) DHPSKMT2ATMIGD3ADORA1HDAC1
SCHEMBL29831351 0.84 DHPS (0.54) DHPSKMT2ATMIGD3ADORA1HDAC1
SCHEMBL17552218 0.83 KDM4E (0.56) MAPTGAADHPSALDH1A1TSHR
SCHEMBL30937970 0.82 KDR (0.61) MAPTGAADHPSALDH1A1MEN1
SCHEMBL29911220 0.82 ALDH1A1 (0.58) MAPTGAAALDH1A1TSHRHSD17B10
SCHEMBL17552211 0.82 ALDH1A1 (0.58) MAPTGAAALDH1A1TSHRHSD17B10
SCHEMBL26798562 0.82 ALDH1A1 (0.58) MAPTGAAALDH1A1TSHRHSD17B10
SCHEMBL17552220 0.81 MAPT (0.60) MAPTGAAALDH1A1TSHRHSD17B10
SCHEMBL29831277 0.81 MAPT (0.60) MAPTGAAALDH1A1TSHRHSD17B10
SCHEMBL25394063 0.81 DHPS (0.50) DHPSTMIGD3ADORA1HDAC1HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250248990-A1 QUINOLINES THAT MODULATE SERCA AND THEIR USE FOR TREATING DISEASE NEURODON CORPORATION 2025-08-07 US disclosed
US-12144806-B2 Quinolines that modulate SERCA and their use for treating disease NEURODON CORPORATION (US) 2024-11-19 US disclosed
US-20240277694-A1 QUINOLINES THAT MODULATE SERCA AND THEIR USE FOR TREATING DISEASE NEURODON CORPORATION 2024-08-22 US disclosed
US-11992487-B2 Quinolines that modulate SERCA and their use for treating disease NEURODON CORPORATION (US) 2024-05-28 US disclosed
EP-4037685-B9 QUINOLINE THAT MODULATE SERCA AND ITS USE FOR TREATING DISEASE NEURODON CORP (US) 2024-03-06 EP disclosed
US-20240016793-A1 QUINOLINES THAT MODULATE SERCA AND THEIR USE FOR TREATING DISEASE NEURODON CORPORATION 2024-01-18 US disclosed
US-20240016793-A1 QUINOLINES THAT MODULATE SERCA AND THEIR USE FOR TREATING DISEASE NEURODON CORPORATION 2024-01-18 US disclosed
US-11827626-B2 Quinolines that modulate SERCA and their use for treating disease NEURODON CORPORATION (US) 2023-11-28 US disclosed
US-11827626-B2 Quinolines that modulate SERCA and their use for treating disease NEURODON CORPORATION (US) 2023-11-28 US disclosed
EP-4037685-B1 QUINOLINE THAT MODULATE SERCA AND ITS USE FOR TREATING DISEASE NEURODON CORP (US) 2023-09-20 EP disclosed
CN-116744928-A Quinolines modulating SERCA and their use for treating diseases 神经元公司 2023-09-12 CN disclosed
US-11730729-B2 Quinolines that modulate SERCA and their use for treating disease NEURODON CORPORATION (US) 2023-08-22 US disclosed
US-11730729-B2 Quinolines that modulate SERCA and their use for treating disease NEURODON CORPORATION (US) 2023-08-22 US disclosed
WO-2022020261-A9 QUINOLINES THAT MODULATE SERCA AND THEIR USE FOR TREATING DISEASE NEURODON CORPORATION (US) 2022-09-09 WO disclosed
US-20220016108-A1 QUINOLINES THAT MODULATE SERCA AND THEIR USE FOR TREATING DISEASE NEURODON CORPORATION 2022-01-20 US disclosed
US-20200347038-A1 QUINOLINES THAT MODULATE SERCA AND THEIR USE FOR TREATING DISEASE NEURODON CORPORATION 2020-11-05 US disclosed
US-10772881-B2 Quinolines that modulate SERCA and their use for treating disease NEURODON CORPORATION 2020-09-15 US disclosed
US-20190151303-A1 QUINOLINES THAT MODULATE SERCA AND THEIR USE FOR TREATING DISEASE NEURODON CORPORATION 2019-05-23 US disclosed
US-20170281611-A1 QUINOLINES AND THEIR USE FOR TREATING ENDOPLASMIC RETICULUM STRESS-CAUSED DISEASES EIGER BIOPHARMACEUTICALS, INC. (US) 2017-10-05 US disclosed
WO-2016032569-A1 QUINOLINES AND THEIR USE FOR TREATING ENDOPLASMIC RETICULUM STRESS-CAUSED DISEASES CELLADON CORPORATION (US) 2016-03-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170281611-A1 QUINOLINES AND THEIR USE FOR TREATING ENDOPLASMIC RETICULUM STRESS-CAUSED DISEASES ATP2A1, ATP2A3, ATP2A2 MAPT 1538/4885GAA 36/4885DHPS 3124/4885
US-11992487-B2 Quinolines that modulate SERCA and their use for treating disease ATP2A1, ATP2A3, ATP2A2 MAPT 1228/4885GAA 94/4885DHPS 3274/4885
US-12144806-B2 Quinolines that modulate SERCA and their use for treating disease ATP2A1, ATP2A3, ATP2A2 MAPT 1228/4885GAA 94/4885DHPS 3274/4885
US-20250248990-A1 QUINOLINES THAT MODULATE SERCA AND THEIR USE FOR TREATING DISEASE ATP2A1, ATP2A3, ATP2A2 MAPT 1228/4885GAA 94/4885DHPS 3274/4885
US-10772881-B2 Quinolines that modulate SERCA and their use for treating disease ATP2A1, ATP2A3, ATP2A2 MAPT 1307/4885GAA 65/4885DHPS 3516/4885
US-11730729-B2 Quinolines that modulate SERCA and their use for treating disease ATP2A1, ATP2A3, ATP2A2 MAPT 1228/4885GAA 94/4885DHPS 3274/4885
US-11827626-B2 Quinolines that modulate SERCA and their use for treating disease ATP2A1, ATP2A3, ATP2A2 MAPT 1228/4885GAA 94/4885DHPS 3274/4885
US-20240277694-A1 QUINOLINES THAT MODULATE SERCA AND THEIR USE FOR TREATING DISEASE ATP2A1, ATP2A3, ATP2A2 MAPT 1228/4885GAA 94/4885DHPS 3274/4885
US-20190151303-A1 QUINOLINES THAT MODULATE SERCA AND THEIR USE FOR TREATING DISEASE ATP2A1, ATP2A3, ATP2A2 MAPT 1307/4885GAA 65/4885DHPS 3516/4885
US-20220016108-A1 QUINOLINES THAT MODULATE SERCA AND THEIR USE FOR TREATING DISEASE ATP2A1, ATP2A3, ATP2A2 MAPT 1228/4885GAA 94/4885DHPS 3274/4885
US-20200347038-A1 QUINOLINES THAT MODULATE SERCA AND THEIR USE FOR TREATING DISEASE ATP2A1, ATP2A3, ATP2A2 MAPT 1228/4885GAA 94/4885DHPS 3274/4885
US-20240016793-A1 QUINOLINES THAT MODULATE SERCA AND THEIR USE FOR TREATING DISEASE ATP2A1, ATP2A3, ATP2A2 MAPT 1228/4885GAA 94/4885DHPS 3274/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.