Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CCR5 | P51681 | 2/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | CDC25A | P30304 | 1/20 | 0.37 |
| ▸ | CDC25B | P30305 | 1/20 | 0.37 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.37 |
| ▸ | HSD17B3 | P37058 | 5/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17560824 | 1.00 | POLB (0.50) | POLBLMNAKDM4EALDH1A1CCR5 | |
| SCHEMBL17560819 | 1.00 | POLB (0.50) | POLBLMNAKDM4EALDH1A1CCR5 | |
| SCHEMBL21283420 | 0.81 | ALDH1A1 (0.49) | POLBKDM4EALDH1A1SLC6A4CDC25A | |
| SCHEMBL21283419 | 0.76 | SLC6A4 (0.44) | POLBLMNAKDM4EALDH1A1SLC6A4 | |
| SCHEMBL19449752 | 0.75 | ALDH1A1 (0.51) | POLBLMNAKDM4EALDH1A1SLC6A4 | |
| Hydrochloric Acid SCHEMBL17560784 | 0.74 | ALDH1A1 (0.50) | POLBLMNAKDM4EALDH1A1SLC6A4 | |
| Hydrochloric Acid SCHEMBL17560785 | 0.74 | ALDH1A1 (0.50) | POLBLMNAKDM4EALDH1A1SLC6A4 | |
| SCHEMBL21882656 | 0.74 | ALDH1A1 (0.52) | POLBLMNAKDM4EALDH1A1SLC6A4 | |
| SCHEMBL19449764 | 0.72 | ALDH1A1 (0.51) | POLBLMNAKDM4EALDH1A1SLC6A4 | |
| SCHEMBL21283424 | 0.72 | ALDH1A1 (0.48) | POLBLMNAKDM4EALDH1A1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10829468-B2 | Methods for treating protozoan infections | NEOCULI PTY LTD. (AU) | 2020-11-10 | — | — | US | claimed |
| US-20200290990-A1 | METHODS FOR TREATING PROTOZOAN INFECTIONS | NEOCULI PTY LTD (AU) | 2020-09-17 | — | — | US | claimed |
| US-10392363-B2 | Methods for treating protozoan infections | NEOCULI PTY LTD. (AU) | 2019-08-27 | — | — | US | claimed |
| US-20170291886-A1 | METHODS FOR TREATING PROTOZOAN INFECTIONS | NEOCULI PTY LTD (AU) | 2017-10-12 | — | — | US | claimed |
| EP-3188722-A1 | METHODS FOR TREATING PROTOZOAN INFECTIONS | Neoculi Pty Ltd (AU) | 2017-07-12 | — | — | EP | claimed |
| WO-2016033635-A1 | METHODS FOR TREATING PROTOZOAN INFECTIONS | NEOCULI PTY LTD (AU) | 2016-03-10 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200290990-A1 | METHODS FOR TREATING PROTOZOAN INFECTIONS | DPM1, ABCB11, PIGS | POLB 3872/4885LMNA 2337/4885KDM4E 3521/4885 |
| US-20170291886-A1 | METHODS FOR TREATING PROTOZOAN INFECTIONS | DPM1, ABCB11, PIGS | POLB 3872/4885LMNA 2337/4885KDM4E 3521/4885 |
| US-10829468-B2 | Methods for treating protozoan infections | DPM1, ABCB11, PIGS | POLB 3872/4885LMNA 2337/4885KDM4E 3521/4885 |
| US-10392363-B2 | Methods for treating protozoan infections | DPM1, ABCB11, PIGS | POLB 3872/4885LMNA 2337/4885KDM4E 3521/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.