Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.37 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17560918 | 1.00 | TDP1 (0.55) | TDP1CYP1A2POLBLMNAKDM4E | |
| SCHEMBL17560915 | 1.00 | TDP1 (0.55) | TDP1CYP1A2POLBLMNAKDM4E | |
| SCHEMBL19449761 | 0.84 | CYP1A2 (0.51) | TDP1CYP1A2POLBLMNAKDM4E | |
| SCHEMBL2771673 | 0.78 | TDP1 (0.56) | TDP1POLBMEN1KMT2AALDH1A1 | |
| SCHEMBL19449767 | 0.74 | TDP1 (0.46) | TDP1POLBKDM4EMEN1KMT2A | |
| SCHEMBL8429957 | 0.72 | TDP1 (0.52) | TDP1POLBLMNAKDM4EMEN1 | |
| SCHEMBL2768439 | 0.72 | TDP1 (0.59) | TDP1POLBMEN1KMT2AALDH1A1 | |
| SCHEMBL17560819 | 0.71 | POLB (0.50) | CYP1A2POLBLMNAKDM4EALDH1A1 | |
| SCHEMBL17560822 | 0.71 | POLB (0.50) | CYP1A2POLBLMNAKDM4EALDH1A1 | |
| SCHEMBL17560824 | 0.71 | POLB (0.50) | CYP1A2POLBLMNAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10829468-B2 | Methods for treating protozoan infections | NEOCULI PTY LTD. (AU) | 2020-11-10 | — | — | US | claimed |
| US-20200290990-A1 | METHODS FOR TREATING PROTOZOAN INFECTIONS | NEOCULI PTY LTD (AU) | 2020-09-17 | — | — | US | claimed |
| US-10392363-B2 | Methods for treating protozoan infections | NEOCULI PTY LTD. (AU) | 2019-08-27 | — | — | US | claimed |
| US-20170291886-A1 | METHODS FOR TREATING PROTOZOAN INFECTIONS | NEOCULI PTY LTD (AU) | 2017-10-12 | — | — | US | claimed |
| EP-3188722-A1 | METHODS FOR TREATING PROTOZOAN INFECTIONS | Neoculi Pty Ltd (AU) | 2017-07-12 | — | — | EP | claimed |
| WO-2016033635-A1 | METHODS FOR TREATING PROTOZOAN INFECTIONS | NEOCULI PTY LTD (AU) | 2016-03-10 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200290990-A1 | METHODS FOR TREATING PROTOZOAN INFECTIONS | DPM1, ABCB11, PIGS | TDP1 3689/4885CYP1A2 110/4885POLB 3872/4885 |
| US-20170291886-A1 | METHODS FOR TREATING PROTOZOAN INFECTIONS | DPM1, ABCB11, PIGS | TDP1 3689/4885CYP1A2 110/4885POLB 3872/4885 |
| US-10829468-B2 | Methods for treating protozoan infections | DPM1, ABCB11, PIGS | TDP1 3689/4885CYP1A2 110/4885POLB 3872/4885 |
| US-10392363-B2 | Methods for treating protozoan infections | DPM1, ABCB11, PIGS | TDP1 3689/4885CYP1A2 110/4885POLB 3872/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.