Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 11/20 | 0.51 |
| ▸ | GYS1 | P13807 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.41 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1756350 | 0.80 | MRGPRX4 (0.51) | MRGPRX4NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL1756417 | 0.77 | MRGPRX4 (0.73) | MRGPRX4 | |
| SCHEMBL1756356 | 0.77 | CCR5 (0.61) | MRGPRX4NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL1762313 | 0.76 | GYS1 (0.80) | GYS1NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL1756400 | 0.72 | GYS1 (0.68) | MRGPRX4GYS1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27623122 | 0.72 | POLB (0.51) | SMN1; SMN2LMNAALDH1A1MAPTHPGD | |
| SCHEMBL12569710 | 0.72 | TDP1 (0.56) | ALDH1A1MAPTHPGDHTTL3MBTL1 | |
| SCHEMBL19075745 | 0.71 | HTT (0.55) | LMNAALDH1A1MAPTHPGDHTT | |
| SCHEMBL19083720 | 0.71 | LRRK2 (0.46) | NPC1LMNAALDH1A1L3MBTL1 | |
| SCHEMBL19083717 | 0.70 | NPC1 (0.42) | NPC1RAB9ASMN1; SMN2LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8039495-B2 | Biphenyl carboxylic acids and bioisosteres as glycogen synthase activators | HOFFMAN-LA ROCHE INC. (US) | 2011-10-18 | — | — | US | disclosed |
| US-8039495-B2 | Biphenyl carboxylic acids and bioisosteres as glycogen synthase activators | HOFFMAN-LA ROCHE INC. (US) | 2011-10-18 | — | — | US | disclosed |
| US-8039495-B2 | Biphenyl carboxylic acids and bioisosteres as glycogen synthase activators | HOFFMAN-LA ROCHE INC. (US) | 2011-10-18 | — | — | US | disclosed |
| US-20110118322-A1 | BIPHENYL CARBOXYLIC ACIDS AND BIOISOSTERES AS GLYCOGEN SYNTHASE ACTIVATORS | BOLIN DAVID ROBERT | 2011-05-19 | — | — | US | disclosed |
| WO-2011058154-A1 | BIPHENYL CARBOXYLIC ACIDS AND BIOISOSTERES AS GLYCOGEN SYNTHASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-05-19 | — | — | WO | disclosed |
| US-20110118322-A1 | BIPHENYL CARBOXYLIC ACIDS AND BIOISOSTERES AS GLYCOGEN SYNTHASE ACTIVATORS | BOLIN DAVID ROBERT | 2011-05-19 | — | — | US | disclosed |
| WO-2011058154-A1 | BIPHENYL CARBOXYLIC ACIDS AND BIOISOSTERES AS GLYCOGEN SYNTHASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-05-19 | — | — | WO | disclosed |
| US-20110118322-A1 | BIPHENYL CARBOXYLIC ACIDS AND BIOISOSTERES AS GLYCOGEN SYNTHASE ACTIVATORS | BOLIN DAVID ROBERT | 2011-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110118322-A1 | BIPHENYL CARBOXYLIC ACIDS AND BIOISOSTERES AS GLYCOGEN SYNTHASE ACTIVATORS | GYS2, GYS1, PYGL | MRGPRX4 3745/4885GYS1 2/4885NPC1 1924/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.