Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 8/20 | 0.47 |
| ▸ | HTR2C | P28335 | 8/20 | 0.47 |
| ▸ | HTR2B | P41595 | 7/20 | 0.34 |
| ▸ | PNMT | P11086 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | ELOVL6 | Q9H5J4 | 1/20 | 0.32 |
| ▸ | KIF11 | P52732 | 2/20 | 0.31 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.30 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.30 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.30 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15389721 | 1.00 | HTR2A (0.47) | HTR2AHTR2CHTR2BPNMTADRB1 | |
| SCHEMBL174028 | 1.00 | HTR2A (0.47) | HTR2AHTR2CHTR2BPNMTADRB1 | |
| SCHEMBL173622 | 0.88 | HTR2A (0.57) | HTR2AHTR2CHTR2BPNMTADRB1 | |
| SCHEMBL174565 | 0.88 | KIF11 (0.34) | HTR2AHTR2CSLC6A2SLC6A4KIF11 | |
| SCHEMBL174466 | 0.86 | HTR2A (0.54) | HTR2AHTR2CHTR2BPNMTADRB1 | |
| SCHEMBL173952 | 0.84 | HTR2A (0.57) | HTR2AHTR2CHTR2BPNMTADRB1 | |
| SCHEMBL28756453 | 0.82 | HTR2A (0.56) | HTR2AHTR2CHTR2BPNMTADRB1 | |
| SCHEMBL171105 | 0.82 | HTR2A (0.56) | HTR2AHTR2CHTR2BPNMTADRB1 | |
| SCHEMBL174234 | 0.77 | HTR2A (0.57) | HTR2AHTR2CHTR2BPNMTADRB1 | |
| SCHEMBL168506 | 0.77 | HTR2A (0.57) | HTR2AHTR2CHTR2BPNMTADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160151381-A1 | SALTS OF LORCASERIN WITH OPTICALLY ACTIVE ACIDS | ARENA PHARMACEUTICALS, INC. | 2016-06-02 | — | — | US | disclosed |
| US-9248133-B2 | Salts of lorcaserin with optically active acids | ARENA PHARMACEUTICALS, INC. (US) | 2016-02-02 | — | — | US | disclosed |
| US-20130310369-A1 | SALTS OF LORCASERIN WITH OPTICALLY ACTIVE ACIDS | ARENA PHARMACEUTICALS, INC | 2013-11-21 | — | — | US | disclosed |
| EP-2611782-A1 | SALTS OF LORCASERIN WITH OPTICALLY ACTIVE ACIDS | Arena Pharmaceuticals, Inc. (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012030938-A1 | SALTS OF LORCASERIN WITH OPTICALLY ACTIVE ACIDS | ARENA PHARMACEUTICALS, INC. (US) | 2012-03-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160151381-A1 | SALTS OF LORCASERIN WITH OPTICALLY ACTIVE ACIDS | CEL, HTR7, HTR1A | HTR2A 9/4885HTR2C 12/4885HTR2B 17/4885 |
| US-20130310369-A1 | SALTS OF LORCASERIN WITH OPTICALLY ACTIVE ACIDS | CEL, HTR7, HTR1A | HTR2A 9/4885HTR2C 12/4885HTR2B 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.