Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1460808 | 0.72 | MAOB (0.42) | MEN1ALDH1A1HTTKMT2APDE10A | |
| SCHEMBL1462783 | 0.58 | ALDH1A1 (0.39) | MEN1ALDH1A1HTTKMT2A | |
| SCHEMBL3787524 | 0.56 | HTT (0.55) | MEN1ALDH1A1HTTKMT2A | |
| SCHEMBL2013872 | 0.54 | CCR1 (0.33) | — | |
| SCHEMBL19942300 | 0.54 | PDE10A (0.38) | ALDH1A1HTTPDE10A | |
| SCHEMBL736971 | 0.54 | NUDT1 (0.50) | ALDH1A1HTTPDE10A | |
| SCHEMBL15760556 | 0.54 | PDE10A (0.38) | MEN1ALDH1A1HTTKMT2APDE10A | |
| SCHEMBL2007375 | 0.54 | ADORA2A (0.52) | — | |
| SCHEMBL8082857 | 0.54 | ADORA2A (0.32) | — | |
| SCHEMBL314774 | 0.54 | ADORA2A (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9284335-B2 | Substituted pyrido[3,2-e][1,2,4]triazolo[1,5-c]pyrimidines, pyrido[2,3-e][1,2,4]triazolo[1,5-c]pyrimidines and/or [1,2,4]triazolo[1,5-c]pteridines for treatment of central nervous system diseases and disorders | DART NEUROSCIENCE (CAYMAN) LTD. (KY) | 2016-03-15 | — | — | US | disclosed |