Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.49 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.43 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2988492 | 0.83 | KDM4E (0.51) | RAB9AKDM4EALDH1A1HSD17B10MEN1 | |
| SCHEMBL13224384 | 0.82 | RAB9A (0.63) | RAB9AKDM4EALDH1A1TSHRTDP1 | |
| SCHEMBL13206688 | 0.80 | RAB9A (0.60) | RAB9AKDM4EALDH1A1TSHRTDP1 | |
| SCHEMBL1757820 | 0.80 | RAB9A (0.60) | RAB9AKDM4EALDH1A1TSHRTDP1 | |
| SCHEMBL11891661 | 0.80 | RAB9A (0.60) | RAB9AKDM4EALDH1A1TSHRTDP1 | |
| SCHEMBL28771222 | 0.77 | ALDH1A1 (0.48) | RAB9AKDM4EALDH1A1TSHRTDP1 | |
| SCHEMBL1779695 | 0.77 | RAB9A (0.68) | RAB9AKDM4EALDH1A1TSHRTDP1 | |
| SCHEMBL3913002 | 0.77 | ALDH1A1 (0.52) | RAB9AKDM4EALDH1A1TSHRTDP1 | |
| SCHEMBL29612923 | 0.77 | ALDH1A1 (0.52) | RAB9AKDM4EALDH1A1TSHRTDP1 | |
| SCHEMBL151122 | 0.76 | KDM4E (0.71) | RAB9AKDM4EALDH1A1TSHRTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110105509-A1 | INDOLE BASED RECEPTOR CRTH2 ANTAGONISTS | WYETH, LLC (US) | 2011-05-05 | — | — | US | disclosed |
| US-20110105509-A1 | INDOLE BASED RECEPTOR CRTH2 ANTAGONISTS | WYETH, LLC (US) | 2011-05-05 | — | — | US | disclosed |
| US-20110105509-A1 | INDOLE BASED RECEPTOR CRTH2 ANTAGONISTS | WYETH, LLC (US) | 2011-05-05 | — | — | US | disclosed |
| US-7781598-B2 | Process for the preparation of substituted indoles | ASTRAZENECA AB (SE) | 2010-08-24 | — | — | US | disclosed |
| US-7781598-B2 | Process for the preparation of substituted indoles | ASTRAZENECA AB (SE) | 2010-08-24 | — | — | US | disclosed |
| US-20080051586-A1 | Novel Process for the Preparation of Substituted Indoles | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | US | disclosed |
| US-20080051586-A1 | Novel Process for the Preparation of Substituted Indoles | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080051586-A1 | Novel Process for the Preparation of Substituted Indoles | IDO1, IDO2, TPH1 | RAB9A 2150/4885KDM4E 565/4885ALDH1A1 882/4885 |
| US-20110105509-A1 | INDOLE BASED RECEPTOR CRTH2 ANTAGONISTS | HRH2, CRHR2, CRHR1 | RAB9A 2524/4885KDM4E 4693/4885ALDH1A1 1069/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.