Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | HTR1D | P28221 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | HTR5A | P47898 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RCE1 | Q9Y256 | 2/20 | 0.31 |
| ▸ | EP300 | Q09472 | 1/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15283382 | 0.82 | TLR8 (0.40) | CHEK1ALDH1A1MAPTKMT2AKDM4E | |
| SCHEMBL12705397 | 0.78 | QDPR (0.44) | CHEK1HTR2CTLR8 | |
| SCHEMBL17580584 | 0.78 | TSHR (0.33) | POLBTSHRCHEK1ALDH1A1MAPT | |
| SCHEMBL25541718 | 0.75 | ALDH1A1 (0.39) | POLBTSHRALDH1A1KDM1AKMT2A | |
| SCHEMBL12705251 | 0.74 | QDPR (0.52) | CHEK1TLR8 | |
| SCHEMBL12705532 | 0.74 | PDE4A (0.48) | POLBTSHRHTR1AEP300 | |
| SCHEMBL25207492 | 0.74 | MEN1 (0.34) | ALDH1A1MAPTKDM1AKMT2AKDM4E | |
| SCHEMBL25541729 | 0.74 | KDM1A (0.33) | ALDH1A1MAPTKDM1AKMT2AMEN1 | |
| SCHEMBL17580522 | 0.73 | CCR5 (0.39) | CHEK1KDM1ATLR8 | |
| SCHEMBL15283319 | 0.72 | HTR1A (0.44) | CHEK1HTR1AHTR1DHTR2CHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2834248-B1 | NOVEL THIENOPYRIMIDINE DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF AND THERAPEUTIC USES THEREOF | SANOFI SA (FR) | 2016-03-16 | — | — | EP | disclosed |