Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SI | P14410 | 1/20 | 0.39 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.39 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1758559 | 0.90 | ALDH1A1 (0.46) | ALDH1A1LMNAHSD17B10KMT2AMEN1 | |
| SCHEMBL758863 | 0.87 | KMT2A (0.48) | ALDH1A1LMNAHSD17B10KMT2AMEN1 | |
| SCHEMBL11422756 | 0.86 | MEN1 (0.43) | ALDH1A1LMNAHSD17B10KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL27831562 | 0.85 | KMT2A (0.46) | ALDH1A1LMNAHSD17B10KMT2AMEN1 | |
| Ammonia Solution, Strong SCHEMBL9456471 | 0.85 | KMT2A (0.46) | ALDH1A1LMNAHSD17B10KMT2AMEN1 | |
| SCHEMBL10960602 | 0.82 | ALDH1A1 (0.39) | ALDH1A1LMNAHSD17B10KMT2AMEN1 | |
| SCHEMBL28755723 | 0.82 | ALDH1A1 (0.42) | ALDH1A1LMNAHSD17B10KMT2AMEN1 | |
| SCHEMBL12763775 | 0.80 | CA12 (0.43) | ALDH1A1LMNAHSD17B10KMT2AMEN1 | |
| SCHEMBL11419403 | 0.79 | CA12 (0.43) | ALDH1A1LMNAHSD17B10KMT2AMEN1 | |
| SCHEMBL2182115 | 0.79 | ALDH1A1 (0.40) | ALDH1A1LMNAHSD17B10KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758916-B1 | 3-BETA-D-RIBOFURANOSYLTHIAZOLO[4,5-d]PYRIDIMINE NUCLEOSIDES AND USES THEREOF | ANADYS PHARMACEUTICALS INC (US) | 2012-11-21 | — | — | EP | disclosed |
| US-7943759-B2 | 3-β-D-ribofuranosylthiazolo[4-5-d]pyrimidine nucleosides and uses thereof | ANADYS PHARMACEUTICALS, INC. (US) | 2011-05-17 | — | — | US | disclosed |
| US-20100261667-A1 | 3-ß-D-RIBOFURANOSYLTHIAZOLO[4-5-d]PYRIMIDINE NUCLEOSIDES AND USES THEREOF | ANADYS PHARMACEUTICALS, INC. (US) | 2010-10-14 | — | — | US | disclosed |
| US-7745415-B2 | 3-β-D-ribofuranosylthiazolo[4,5-d]pyrimidine nucleosides and uses thereof | ANADYS PHARMACEUTICALS, INC. (US) | 2010-06-29 | — | — | US | disclosed |
| US-20080255063-A1 | 3-B-D-RIBOFURANOSYLTHIAZOLO[4,5-d]PYRIMIDINE NUCLEOSIDES AND USES THEREOF | ANADYS PHARMACEUTICALS, INC. (US) | 2008-10-16 | — | — | US | disclosed |
| US-20080070852-A1 | 3-Beta-D-Ribofuranosylthiazolo[ 4,5-D] Pyridimine Nucleosides and Uses Thereof | ANADYS PHARMACEUTICALS, INC. | 2008-03-20 | — | — | US | disclosed |
| US-7321033-B2 | 3-B-D-ribofuranosylthiazolo [4,5-d] pyrimidine nucleosides and uses thereof | ANADYS PHARMACEUTICALS, INC. (US) | 2008-01-22 | — | — | US | disclosed |
| US-20050070556-A1 | 3-B-D-ribofuranosylthiazolo [4,5-d] pyridimine nucleosides and uses thereof | ANADYS PHARMACEUTICALS, INC. (US) | 2005-03-31 | — | — | US | disclosed |
| US-4008222-A | POLYESTERS | BAYER AKTIENGESELLSCHAFT (DT) | 1977-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255063-A1 | 3-B-D-RIBOFURANOSYLTHIAZOLO[4,5-d]PYRIMIDINE NUCLEOSIDES AND USES THEREOF | DPYD, TYMP, DCTD | ALDH1A1 904/4885LMNA 3476/4885HSD17B10 3966/4885 |
| US-20100261667-A1 | 3-ß-D-RIBOFURANOSYLTHIAZOLO[4-5-d]PYRIMIDINE NUCLEOSIDES AND USES THEREOF | TYMP, DPYD, NUDT1 | ALDH1A1 818/4885LMNA 3389/4885HSD17B10 4068/4885 |
| US-20080070852-A1 | 3-Beta-D-Ribofuranosylthiazolo[ 4,5-D] Pyridimine Nucleosides and Uses Thereof | ADORA2B, DPYD, ADAR | ALDH1A1 1059/4885LMNA 1741/4885HSD17B10 3619/4885 |
| US-20050070556-A1 | 3-B-D-ribofuranosylthiazolo [4,5-d] pyridimine nucleosides and uses thereof | ENTPD5, DPYD, TYMP | ALDH1A1 1278/4885LMNA 1907/4885HSD17B10 4122/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.