Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 8/20 | 0.59 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.41 |
| ▸ | NCOA2 | Q15596 | 2/20 | 0.41 |
| ▸ | NCOA1 | Q15788 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.41 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17582539 | 0.81 | NPBWR1 (0.50) | PIK3CDPIK3CBPIK3CGPIK3CAALDH1A1 | |
| SCHEMBL17582593 | 0.81 | PIK3CD (0.48) | PIK3CDPIK3CBPIK3CGPIK3CAALDH1A1 | |
| SCHEMBL17582589 | 0.76 | PTGS2 (0.55) | PIK3CDPIK3CBPIK3CGPIK3CAALDH1A1 | |
| SCHEMBL17582583 | 0.76 | PIK3CD (0.46) | PIK3CDPIK3CBPIK3CGPIK3CAALDH1A1 | |
| SCHEMBL17582598 | 0.74 | PIK3CD (0.85) | PIK3CDPIK3CBPIK3CGPIK3CA | |
| SCHEMBL17582584 | 0.68 | PTGS1 (0.50) | ALDH1A1HTTLMNAHPGDPPARG | |
| SCHEMBL20444062 | 0.67 | KDM5B (0.48) | ALDH1A1HTTLMNAHPGDPPARG | |
| SCHEMBL19000720 | 0.65 | TSHR (0.61) | ALDH1A1HTTLMNAHPGDPPARG | |
| SCHEMBL20443987 | 0.65 | PTGS1 (0.49) | ALDH1A1HTTLMNAHPGDPPARG | |
| SCHEMBL4253339 | 0.64 | NR2E3 (0.48) | ALDH1A1HTTLMNANPSR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3191491-B1 | PYRIDAZINONE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS | CHIESI FARM SPA (IT) | 2019-09-04 | — | — | EP | disclosed |
| EP-3191491-B1 | PYRIDAZINONE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS | CHIESI FARM SPA (IT) | 2019-09-04 | — | — | EP | disclosed |
| US-9745308-B2 | Pyridazinone derivatives as phoshoinositide 3-kinases inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2017-08-29 | — | — | US | disclosed |
| US-9745308-B2 | Pyridazinone derivatives as phoshoinositide 3-kinases inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2017-08-29 | — | — | US | disclosed |
| US-9745308-B2 | Pyridazinone derivatives as phoshoinositide 3-kinases inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2017-08-29 | — | — | US | disclosed |
| EP-3191491-A1 | PYRIDAZINONE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2017-07-19 | — | — | EP | disclosed |
| WO-2016038140-A1 | PYRIDAZINONE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2016-03-17 | — | — | WO | disclosed |
| US-20160075710-A1 | PYRIDAZINONE DERIVATIVES AS PHOSHOINOSITIDE 3-KINASES INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2016-03-17 | — | — | US | disclosed |
| US-20160075710-A1 | PYRIDAZINONE DERIVATIVES AS PHOSHOINOSITIDE 3-KINASES INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2016-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160075710-A1 | PYRIDAZINONE DERIVATIVES AS PHOSHOINOSITIDE 3-KINASES INHIBITORS | PIP4K2B, PIP5K1B, PIK3CA | PIK3CD 9/4885PIK3CB 5/4885PIK3CG 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.