Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 3/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.49 |
| ▸ | HTT | P42858 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | MITF | O75030 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17582593 | 0.81 | PIK3CD (0.48) | NPBWR1PIK3CDHTTALDH1A1NPSR1 | |
| SCHEMBL17582607 | 0.81 | PIK3CD (0.59) | NPBWR1PIK3CDHTTALDH1A1NPSR1 | |
| SCHEMBL1691901 | 0.76 | HTT (0.71) | NPBWR1HTTALDH1A1NPSR1LMNA | |
| SCHEMBL17582583 | 0.76 | PIK3CD (0.46) | NPBWR1PIK3CDALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL29451810 | 0.74 | MITF (0.47) | HTTALDH1A1NPSR1LMNASMN1; SMN2 | |
| SCHEMBL25341629 | 0.74 | NPBWR1 (0.60) | NPBWR1HTTALDH1A1NPSR1LMNA | |
| SCHEMBL31174056 | 0.74 | HTT (0.59) | NPBWR1HTTALDH1A1NPSR1LMNA | |
| SCHEMBL4383612 | 0.73 | NPBWR1 (0.75) | NPBWR1HTTALDH1A1NPSR1LMNA | |
| SCHEMBL4800431 | 0.69 | PTGS2 (0.54) | NPBWR1HTTALDH1A1NPSR1LMNA | |
| SCHEMBL4356807 | 0.69 | RECQL (0.55) | NPBWR1HTTALDH1A1NPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3191491-B1 | PYRIDAZINONE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS | CHIESI FARM SPA (IT) | 2019-09-04 | — | — | EP | disclosed |
| EP-3191491-B1 | PYRIDAZINONE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS | CHIESI FARM SPA (IT) | 2019-09-04 | — | — | EP | disclosed |
| US-9745308-B2 | Pyridazinone derivatives as phoshoinositide 3-kinases inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2017-08-29 | — | — | US | disclosed |
| US-9745308-B2 | Pyridazinone derivatives as phoshoinositide 3-kinases inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2017-08-29 | — | — | US | disclosed |
| US-9745308-B2 | Pyridazinone derivatives as phoshoinositide 3-kinases inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2017-08-29 | — | — | US | disclosed |
| EP-3191491-A1 | PYRIDAZINONE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2017-07-19 | — | — | EP | disclosed |
| WO-2016038140-A1 | PYRIDAZINONE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2016-03-17 | — | — | WO | disclosed |
| US-20160075710-A1 | PYRIDAZINONE DERIVATIVES AS PHOSHOINOSITIDE 3-KINASES INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2016-03-17 | — | — | US | disclosed |
| US-20160075710-A1 | PYRIDAZINONE DERIVATIVES AS PHOSHOINOSITIDE 3-KINASES INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2016-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160075710-A1 | PYRIDAZINONE DERIVATIVES AS PHOSHOINOSITIDE 3-KINASES INHIBITORS | PIP4K2B, PIP5K1B, PIK3CA | NPBWR1 3144/4885PIK3CD 9/4885HTT 4372/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.