Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.48 |
| ▸ | NPBWR1 | P48145 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | HTT | P42858 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | PPARG | P37231 | 2/20 | 0.45 |
| ▸ | NCOA2 | Q15596 | 2/20 | 0.45 |
| ▸ | NCOA1 | Q15788 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27772589 | 0.81 | NPBWR1 (0.43) | KDM5BNPBWR1ALDH1A1HTTLMNA | |
| SCHEMBL27772593 | 0.80 | NR2E3 (0.44) | KDM5BNPBWR1ALDH1A1HTTLMNA | |
| SCHEMBL21721655 | 0.80 | P2RX7 (0.47) | KDM5BNPBWR1ALDH1A1LMNAHPGD | |
| SCHEMBL16448707 | 0.78 | RAB9A (0.37) | NPBWR1ALDH1A1HTTNPSR1HPGD | |
| SCHEMBL14722888 | 0.77 | NPBWR1 (0.49) | NPBWR1ALDH1A1HTTLMNANPSR1 | |
| SCHEMBL4256751 | 0.77 | ALDH1A1 (0.47) | NPBWR1ALDH1A1SMN1; SMN2KDM4ENR2E3 | |
| SCHEMBL38650588 | 0.75 | NPBWR1 (0.37) | NPBWR1ALDH1A1HTTLMNANPSR1 | |
| SCHEMBL12376650 | 0.75 | BRD4 (0.49) | NPBWR1ALDH1A1HTTHPGDSMN1; SMN2 | |
| SCHEMBL31338870 | 0.74 | ALDH1A1 (0.47) | NPBWR1ALDH1A1HTTLMNANPSR1 | |
| SCHEMBL20444069 | 0.73 | GAA (0.46) | NPBWR1ALDH1A1HTTLMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10253000-B2 | Pyridazin-3(2H)-one derivatives as monoamine oxidase selective isoform B inhibitors | UNIVERSIDADE DE VIGO (ES) | 2019-04-09 | — | — | US | disclosed |
| US-20180215718-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AS MONOAMINE OXIDASE SELECTIVE ISOFORM B INHIBITORS (As Amended) | UNIVERSIDADE DE VIGO (ES) | 2018-08-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180215718-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AS MONOAMINE OXIDASE SELECTIVE ISOFORM B INHIBITORS (As Amended) | MAOB, MAOA, AOC3 | KDM5B 302/4885NPBWR1 2293/4885ALDH1A1 331/4885 |
| US-10253000-B2 | Pyridazin-3(2H)-one derivatives as monoamine oxidase selective isoform B inhibitors | MAOB, MAOA, AOC3 | KDM5B 253/4885NPBWR1 2033/4885ALDH1A1 351/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.