SCHEMBL1758404

SCHEMBL1758404

CN(N)c1ccc(Cl)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 2/20 0.48
CA1 P00915 2/20 0.48
CA2 P00918 2/20 0.48
AOC3 Q16853 3/20 0.46
ALDH1A1 P00352 5/20 0.45
ALOX15 P16050 3/20 0.45
HSD17B10 Q99714 2/20 0.45
KDM4E B2RXH2 1/20 0.45
HPGD P15428 1/20 0.45
LMNA P02545 1/20 0.44
CYP2A6 P11509 1/20 0.44
TDP1 Q9NUW8 3/20 0.41
POLB P06746 1/20 0.41
ADRB2 P07550 1/20 0.39
CHKA P35790 2/20 0.38
TSHR P16473 2/20 0.38
CA3 P07451 1/20 0.37
CA4 P22748 1/20 0.37
CA6 P23280 1/20 0.37
CA5A P35218 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8401393 0.97 CA12 (0.46) CA12CA1CA2AOC3ALDH1A1
SCHEMBL5213200 0.77 CHKA (0.55) ALDH1A1ALOX15HSD17B10KDM4EHPGD
SCHEMBL31116653 0.77 ALDH1A1 (0.69) ALDH1A1ALOX15HSD17B10KDM4EHPGD
SCHEMBL59751 0.77 ALDH1A1 (0.69) ALDH1A1ALOX15HSD17B10KDM4EHPGD
SCHEMBL8162988 0.74 ALDH1A1 (0.65) ALDH1A1ALOX15HSD17B10KDM4EHPGD
SCHEMBL3520281 0.74 ALDH1A1 (0.60) CA12CA1CA2ALDH1A1ALOX15
SCHEMBL11266187 0.74 LMNA (0.47) CA12CA1CA2AOC3ALDH1A1
Hydrochloric Acid SCHEMBL2876035 0.74 ALDH1A1 (0.65) ALDH1A1ALOX15HSD17B10KDM4EHPGD
Hydrochloric Acid SCHEMBL6414496 0.74 CHKA (0.53) ALDH1A1ALOX15HSD17B10KDM4EHPGD
Ethane SCHEMBL6986774 0.74 CHKA (0.53) ALDH1A1ALOX15HSD17B10KDM4EHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114349656-B Preparation method of hydrazide compound 赣南师范大学 2024-03-29 CN claimed
CN-116003336-B 1,2, 4-Triazole-3-amine compound, and preparation method and application thereof 赣南师范大学 2024-11-05 CN disclosed
CN-114349656-B Preparation method of hydrazide compound 赣南师范大学 2024-03-29 CN disclosed
CN-116003336-A 1,2, 4-triazole-3-amine compound, and preparation method and application thereof 赣南师范大学 2023-04-25 CN disclosed
CN-112812040-B Amidine acylhydrazone compound and preparation method thereof 赣南师范大学 2023-03-31 CN disclosed
CN-114349656-A Preparation method of hydrazide compound 赣南师范大学 2022-04-15 CN disclosed
CN-112812040-A Amidine acylhydrazone compound and preparation method thereof 赣南师范大学 2021-05-18 CN disclosed
US-20200231583-A1 Prostaglandin E Synthase Inhibitors and Methods for Utilizing the Same UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION 2020-07-23 US disclosed
EP-1856057-B1 TETRAHYDROINDOLONE AND TETRAHYDROINDAZOLONE DERIVATIVES SERENEX INC (US) 2014-10-15 EP disclosed
WO-2011051958-A1 FUNGICIDAL PYRAZOLONES E.I. DU PONT DE NEMOURS AND COMPANY (US) 2011-05-05 WO disclosed
CN-1156446-A carbamoyl carbohydrazide BASF AG (DE) 1997-08-06 CN disclosed
US-5223362-A Multilayer; electroconductive substrate, charge transfer and charge generating compound BANDO CHEMICAL INDUSTRIES, LTD. (JP) 1993-06-29 US disclosed
EP-0410285-A1 Laminated organic photosensitive material BANDO CHEMICAL INDUSTRIES, LIMITED (JP) 1991-01-30 EP disclosed
EP-0040583-B1 PROCESS FOR THE PREPARATION OF A UV-ABSORBING MASK CIBA-GEIGY AG (CH) 1988-01-13 EP disclosed
EP-0034285-B1 PROCESS FOR THE PREPARATION OF 1-ALKYL-1-PHENYL HYDRAZINES HOECHST AKTIENGESELLSCHAFT (DE) 1985-11-06 EP disclosed
EP-0137746-A2 Nitrogen substituted angiotensin converting enzyme inhibitors FISONS plc (GB) 1985-04-17 EP disclosed
US-4435489-A ULTRAVIOLET ABSORBER IN POLYMER BINDERS AND COATINGS CIBA-GEIGY AG (CH) 1984-03-06 US disclosed
US-4383948-A Hydrazone derivatives containing a quaternary ammonium group useful as UV absorbers CIBA-GEIGY AG (CH) 1983-05-17 US disclosed
EP-0040583-A1 Process for the preparation of a UV-absorbing mask CIBA-GEIGY AG (CH) 1981-11-25 EP disclosed
EP-0034285-A2 Process for the preparation of 1-alkyl-1-phenyl hydrazines HOECHST AKTIENGESELLSCHAFT (DE) 1981-08-26 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200231583-A1 Prostaglandin E Synthase Inhibitors and Methods for Utilizing the Same PTGES, PTGS1, PTGES2 CA12 4225/4885CA1 2489/4885CA2 2020/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.