Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 6/20 | 0.62 |
| ▸ | PSEN2 | P49810 | 6/20 | 0.62 |
| ▸ | APH1B | Q8WW43 | 6/20 | 0.62 |
| ▸ | NCSTN | Q92542 | 6/20 | 0.62 |
| ▸ | APH1A | Q96BI3 | 6/20 | 0.62 |
| ▸ | PSENEN | Q9NZ42 | 6/20 | 0.62 |
| ▸ | SGK1 | O00141 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 3/20 | 0.38 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.38 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16235297 | 0.84 | PSEN1 (0.53) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1972231 | 0.84 | IDO1 (0.46) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL16046605 | 0.82 | PSEN1 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL2376623 | 0.80 | PSEN1 (0.57) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL30408547 | 0.80 | PSEN1 (0.57) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL2376628 | 0.80 | PSEN1 (0.57) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL14378223 | 0.78 | PSEN1 (0.56) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4428882 | 0.78 | PSEN1 (0.44) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4834548 | 0.78 | IDO1 (0.50) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3256690 | 0.77 | ALDH1A1 (0.51) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3126329-B1 | N-HYDROXYMETHANESULFONAMIDE NITROXYL DONORS | CARDIOXYL PHARMACEUTICALS INC (US) | 2019-05-29 | — | — | EP | disclosed |
| US-9932303-B2 | N-hydroxymethanesulfonamide nitroxyl donors | CARDIOXYL PHARMACEUTICALS, INC. (US) | 2018-04-03 | — | — | US | disclosed |
| EP-3126329-A1 | N-HYDROXYMETHANESULFONAMIDE NITROXYL DONORS | Cardioxyl Pharmaceuticals Inc. (US) | 2017-02-08 | — | — | EP | disclosed |
| CN-102712634-B | Heteroaryl piperidine and heteroaryl bridged piperazine derivatives | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2016-04-06 | — | — | CN | disclosed |
| US-20160046569-A1 | N-HYDROXYMETHANESULFONAMIDE NITROXYL DONORS | CARDIOXYL PHARMACEUTICALS, INC. | 2016-02-18 | — | — | US | disclosed |
| WO-2015109210-A1 | N-HYDROXYMETHANESULFONAMIDE NITROXYL DONORS | CARDIOXYL PHARMACEUTICALS, INC. (US) | 2015-07-23 | — | — | WO | disclosed |
| EP-2493886-B1 | HETEROARYL PIPERIDINE AND PIPERAZINE DERIVATES | BAYER CROPSCIENCE AG (DE) | 2014-11-26 | — | — | EP | disclosed |
| US-8501781-B2 | Heteroarylpiperidine and -piperazine derivatives | BAYER CROPSCIENCE AG (DE) | 2013-08-06 | — | — | US | disclosed |
| EP-2493886-A1 | HETEROARYLPIPERIDINE AND -PIPERAZINE DERIVATIVES | Bayer CropScience AG (DE) | 2012-09-05 | — | — | EP | disclosed |
| US-20110306620-A1 | Heteroarylpiperidine And-Piperazine Derivatives | BAYER CROPSCIENCE AG (DE) | 2011-12-15 | — | — | US | disclosed |
| WO-2011051244-A1 | HETEROARYLPIPERIDINE AND -PIPERAZINE DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2011-05-05 | — | — | WO | disclosed |
| US-7655675-B2 | Gamma-secretase inhibitors | MERCK SHARP & DOHME LIMITED (GB) | 2010-02-02 | — | — | US | disclosed |
| US-20050075320-A1 | Gamma-secretase inhibitors | MERCK SHARP & DOHME LTD. (GB) | 2005-04-07 | — | — | US | disclosed |
| EP-0804464-B1 | AROMATIC HETEROCYCLIC DERIVATIVES AS ENZYME INHIBITORS | CORVAS INT INC (US) | 2002-05-08 | — | — | EP | disclosed |
| WO-1997046207-A2 | AROMATIC HETEROCYCLIC DERIVATIVES AS ENZYME INHIBITORS | CORVAS INTERNATIONAL, INC. (US) | 1997-12-11 | — | — | WO | disclosed |
| EP-0804464-A1 | AROMATIC HETEROCYCLIC DERIVATIVES AS ENZYME INHIBITORS | CORVAS INTERNATIONAL, INC. (US) | 1997-11-05 | — | — | EP | disclosed |
| WO-1996018644-A1 | AROMATIC HETEROCYCLIC DERIVATIVES AS ENZYME INHIBITORS | CORVAS INTERNATIONAL, INC. (US) | 1996-06-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110306620-A1 | Heteroarylpiperidine And-Piperazine Derivatives | CAT, DPM1, ERG28 | PSEN1 1846/4885PSEN2 2258/4885APH1B 1173/4885 |
| US-20050075320-A1 | Gamma-secretase inhibitors | BACE1, BACE2, APP | PSEN1 4/4885PSEN2 5/4885APH1B 9/4885 |
| US-20160046569-A1 | N-HYDROXYMETHANESULFONAMIDE NITROXYL DONORS | TNNI3, TNNC1, TNNT2 | PSEN1 1132/4885PSEN2 994/4885APH1B 3235/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.