Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 11/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.39 |
| ▸ | PDE1A | P54750 | 3/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.39 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1758679 | 0.90 | PDE5A (0.41) | PDE5AKDM4EHDAC6PDE1APDE1B | |
| SCHEMBL1758740 | 0.88 | PDE5A (0.37) | PDE5AKDM4EHDAC6PDE1APDE1B | |
| SCHEMBL1758935 | 0.88 | PDE5A (0.39) | PDE5AKDM4EPDE1APDE1BPDE1C | |
| SCHEMBL1758680 | 0.79 | ALDH1A1 (0.42) | PDE5AKDM4EHDAC6PDE1APDE1B | |
| SCHEMBL1758659 | 0.79 | PDE5A (0.38) | PDE5AKDM4EPDE1APDE1BPDE1C | |
| SCHEMBL1758936 | 0.76 | MAPT (0.38) | PDE5AKDM4EHDAC6PDE1APDE1B | |
| SCHEMBL1758713 | 0.75 | PDE5A (0.54) | PDE5AKDM4EPDE1APDE1BPDE1C | |
| SCHEMBL1758672 | 0.74 | HDAC1 (0.41) | PDE5AKDM4EHDAC6PDE1APDE1B | |
| SCHEMBL1759205 | 0.71 | CNR2 (0.62) | PDE5AKDM4EPDE1APDE1BPDE1C | |
| SCHEMBL3604375 | 0.71 | PDE5A (0.44) | PDE5AKDM4EHDAC6PDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011058582-A1 | HISTONE DEACETYLASE INHIBITORS FOR THE TREATMENT OF FUNGAL INFECTIONS | ORCHID RESEARCH LABORATORIES LTD. (IN) | 2011-05-19 | — | — | WO | claimed |
| WO-2011058582-A1 | HISTONE DEACETYLASE INHIBITORS FOR THE TREATMENT OF FUNGAL INFECTIONS | ORCHID RESEARCH LABORATORIES LTD. (IN) | 2011-05-19 | — | — | WO | disclosed |