SCHEMBL17590551

SCHEMBL17590551

COC(=O)C(C)(C)CC(C)c1ccc(Cl)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGES2 Q9H7Z7 1/20 0.43
L3MBTL1 Q9Y468 2/20 0.43
GRIN2D O15399 1/20 0.42
GRIN3B O60391 1/20 0.42
GRIN1 Q05586 1/20 0.42
GRIN2A Q12879 1/20 0.42
GRIN2B Q13224 1/20 0.42
GRIN2C Q14957 1/20 0.42
GRIN3A Q8TCU5 1/20 0.42
CYP26A1 O43174 1/20 0.41
FFAR2 O15552 1/20 0.41
CNR1 P21554 3/20 0.40
CNR2 P34972 3/20 0.40
MEN1 O00255 3/20 0.40
KMT2A Q03164 3/20 0.40
RAB9A P51151 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
CYP3A4 P08684 3/20 0.38
CYP1A2 P05177 2/20 0.38
CYP2D6 P10635 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13197307 0.86 ALDH1A1 (0.46) L3MBTL1MEN1KMT2ARAB9ASMN1; SMN2
SCHEMBL25604264 0.84 KMT2A (0.44) MEN1KMT2ARAB9ACYP3A4CYP2C19
SCHEMBL11910301 0.74 ADRB2 (0.46) PTGES2FFAR2MEN1KMT2ATSHR
SCHEMBL6469058 0.73 GRN (0.50) PTGES2L3MBTL1MEN1KMT2ACYP3A4
SCHEMBL16812545 0.73 HDAC8 (0.46) L3MBTL1CNR2CYP3A4NPSR1
SCHEMBL12268192 0.73 L3MBTL1 (0.50) L3MBTL1FFAR2CNR2MEN1KMT2A
SCHEMBL17451235 0.73 L3MBTL1 (0.50) L3MBTL1FFAR2CNR2MEN1KMT2A
SCHEMBL27644593 0.73 CYP2C9 (0.41) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
SCHEMBL26239387 0.73 CYP2D6 (0.40) PTGES2L3MBTL1GRIN2DGRIN3BGRIN1
SCHEMBL12121918 0.72 GSK3B (0.48) L3MBTL1MEN1KMT2ARAB9ACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2604595-B1 TRIAZINE DERIVATIVE AND PHARMACEUTICAL COMPOUND THAT CONTAINS SAME AND EXHIBITS ANALGESIC ACTIVITY SHIONOGI & CO (JP) 2016-03-16 EP disclosed