Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.42 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17595028 | 0.92 | ALDH1A1 (0.42) | LMNAMAPTALDH1A1GPR119DDB1 | |
| SCHEMBL14745432 | 0.85 | MAPT (0.47) | LMNAMAPTALDH1A1GPR119DDB1 | |
| SCHEMBL17595142 | 0.82 | ABCB1 (0.39) | LMNAMAPTALDH1A1GPR119DDB1 | |
| SCHEMBL14745604 | 0.75 | POLB (0.43) | LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL17595141 | 0.74 | ABCB1 (0.40) | LMNAMAPTALDH1A1GPR119DDB1 | |
| SCHEMBL14745621 | 0.73 | L3MBTL1 (0.43) | LMNAMAPTALDH1A1GPR119SMN1; SMN2 | |
| SCHEMBL14746007 | 0.72 | MAPT (0.45) | LMNAMAPTALDH1A1GPR119DDB1 | |
| SCHEMBL14744882 | 0.72 | EZH2 (0.38) | MAPTTGFBR1 | |
| SCHEMBL3807661 | 0.71 | MAPT (0.64) | LMNAMAPTALDH1A1GPR119DDB1 | |
| SCHEMBL14745092 | 0.70 | PARP1 (0.43) | LMNAMAPTALDH1A1SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016039936-A2 | MONOCYCLIC SUBSTITUTED 2-PYRIDINONE ANTIBACTERIAL COMPOUNDS | PTC THERAPEUTICS, INC. (US) | 2016-03-17 | — | — | WO | claimed |