SCHEMBL17596455

SCHEMBL17596455

COC(=O)C(=Cc1cccnc1Cc1ccccc1)C(=O)OC

nearest known ligand 0.50

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.47
NPSR1 Q6W5P4 1/20 0.47
HSP90AA1 P07900 1/20 0.43
LMNA P02545 3/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
POLB P06746 2/20 0.40
MEN1 O00255 1/20 0.40
PLIN1 O60240 1/20 0.40
PLIN5 Q00G26 1/20 0.40
KMT2A Q03164 1/20 0.40
ABHD5 Q8WTS1 1/20 0.40
L3MBTL1 Q9Y468 2/20 0.40
PKM P14618 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17595558 0.75 TRIM24 (0.48) NPSR1HSP90AA1LMNASMN1; SMN2MEN1
SCHEMBL4500023 0.73 L3MBTL1 (0.60) MAPTNPSR1HSP90AA1LMNAPOLB
SCHEMBL13607458 0.72 HSP90AA1 (0.54) MAPTNPSR1HSP90AA1LMNASMN1; SMN2
SCHEMBL28183445 0.72 KDM4E (0.42)
SCHEMBL10372510 0.71 MAPT (0.43) MAPTNPSR1LMNASMN1; SMN2POLB
SCHEMBL11633202 0.70 KDM4E (0.41) HSP90AA1
SCHEMBL20767516 0.70 KDM4E (0.41) MEN1KMT2AL3MBTL1
SCHEMBL971350 0.70 L3MBTL1 (0.50) MAPTNPSR1HSP90AA1SMN1; SMN2POLB
SCHEMBL29489366 0.69 MAPT (0.61) MAPTNPSR1LMNASMN1; SMN2POLB
SCHEMBL15913856 0.69 MAPT (0.61) MAPTNPSR1LMNASMN1; SMN2POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106715425-B Herbicidal quinolines 先正达参股股份有限公司 2020-11-06 CN disclosed
EP-3191465-B1 HERBICIDAL QUINOLINES SYNGENTA PARTICIPATIONS AG (CH) 2018-12-19 EP disclosed
US-9980486-B2 Herbicidal quinolines SYNGENTA PARTICIPATIONS AG (CH) 2018-05-29 US disclosed
US-20170251670-A1 HERBICIDAL QUINOLINES SYNGENTA PARTICIPATIONS AG (CH) 2017-09-07 US disclosed
EP-3191465-A1 HERBICIDAL QUINOLINES Syngenta Participations AG (CH) 2017-07-19 EP disclosed
WO-2016038173-A1 HERBICIDAL QUINOLINES SYNGENTA PARTICIPATIONS AG (CH) 2016-03-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170251670-A1 HERBICIDAL QUINOLINES NQO2, DDT, ATP1B1 MAPT 3589/4885NPSR1 1146/4885HSP90AA1 1351/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.