Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 3/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 2/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17597441 | 0.84 | METAP2 (0.38) | PPARGMETAP2ABL1ACACBEGLN2 | |
| SCHEMBL17597840 | 0.80 | METAP2 (0.40) | PPARGMETAP2ABL1DGAT2ACACB | |
| SCHEMBL17913308 | 0.77 | IRAK4 (0.35) | PPARGABL1EGLN2EGLN1GRM5 | |
| SCHEMBL17597511 | 0.77 | DRD2 (0.38) | PPARGFFAR4METAP2ALDH1A1EGLN2 | |
| SCHEMBL17597287 | 0.75 | PPARG (0.40) | PPARGFFAR4METAP2NAMPTALDH1A1 | |
| SCHEMBL17597319 | 0.74 | ALDH1A1 (0.43) | FFAR4ALDH1A1 | |
| SCHEMBL17597419 | 0.73 | CA12 (0.37) | PPARGFFAR4METAP2ALDH1A1GRM5 | |
| SCHEMBL17597779 | 0.71 | CA12 (0.38) | PPARGFFAR4METAP2ALDH1A1 | |
| SCHEMBL17597797 | 0.67 | CNR2 (0.42) | — | |
| SCHEMBL17597812 | 0.66 | DRD2 (0.39) | PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016040764-A1 | CARBONYL LINKED BICYCLIC HETEROARYL N-BENZIMIDAZOLES AND ANALOGS AS ANTIBIOTIC TOLERANCE INHIBITORS | SPERO THERAPEUTICS, INC. (US) | 2016-03-17 | — | — | WO | disclosed |