Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 7/20 | 0.55 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 3/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 7/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17612855 | 0.90 | CTSB (0.52) | KEAP1CTSBALDH1A1MAPT | |
| SCHEMBL17599448 | 0.82 | KEAP1 (0.73) | KEAP1NFE2L2CTSBNOTUMALDH1A1 | |
| SCHEMBL17612888 | 0.77 | KEAP1 (0.52) | KEAP1NFE2L2NOTUM | |
| SCHEMBL17612878 | 0.75 | KEAP1 (0.67) | KEAP1NFE2L2NOTUM | |
| SCHEMBL17612882 | 0.74 | CTSB (0.50) | KEAP1CTSBALDH1A1MAPT | |
| SCHEMBL17599504 | 0.71 | KEAP1 (0.65) | KEAP1NFE2L2 | |
| SCHEMBL17599418 | 0.71 | KEAP1 (1.00) | KEAP1NFE2L2CTSBNOTUMALDH1A1 | |
| SCHEMBL17612884 | 0.71 | KEAP1 (1.00) | KEAP1NFE2L2CTSBNOTUMALDH1A1 | |
| SCHEMBL17599451 | 0.71 | KEAP1 (1.00) | KEAP1NFE2L2CTSBNOTUMALDH1A1 | |
| SCHEMBL17612907 | 0.71 | KEAP1 (0.48) | KEAP1NFE2L2NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997966-A1 | Naphthyl Sulfonamide Pyrrolidine Derivatives as KEAP-1 Modulators for the Treatment of Diabetes, Obesity, Dyslipidemia and Related Disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |