Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 4/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.38 |
| ▸ | TLR2 | O60603 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | CDC25B | P30305 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17599527 | 0.90 | SLC6A3 (0.53) | SLC6A2SLC6A3KMT2AKDM4EMEN1 | |
| SCHEMBL17599453 | 0.85 | KEAP1 (0.46) | KMT2AKDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL17614083 | 0.76 | KEAP1 (0.41) | KMT2AKDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL17599550 | 0.76 | KEAP1 (0.41) | KMT2AKDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL17599499 | 0.74 | KEAP1 (0.48) | SLC6A2SLC6A3KMT2AKDM4EMEN1 | |
| SCHEMBL17599467 | 0.72 | KMT2A (0.55) | KMT2AKDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL17599470 | 0.71 | MEN1 (0.46) | KMT2AKDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL17599510 | 0.71 | KMT2A (0.53) | KMT2AKDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL17599548 | 0.70 | NPSR1 (0.53) | KMT2AKDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL17614106 | 0.70 | KEAP1 (0.50) | KMT2AKDM4EMEN1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2998292-A1 | Naphthyl sulfonamide derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | claimed |
| EP-2998292-A1 | Naphthyl sulfonamide derivatives as KEAP-1 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders | SANOFI (FR) | 2016-03-23 | — | — | EP | disclosed |