Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | RXRB | P28702 | 1/20 | 0.43 |
| ▸ | RXRG | P48443 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 5/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 5/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.33 |
| ▸ | IL1B | P01584 | 1/20 | 0.33 |
| ▸ | PDE9A | O76083 | 2/20 | 0.33 |
| ▸ | PDE1A | P54750 | 2/20 | 0.32 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.32 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20818033 | 0.88 | RXRA (0.43) | RXRARXRBRXRGALDH1A1LMNA | |
| SCHEMBL22941287 | 0.88 | RXRA (0.45) | RXRARXRBRXRGALDH1A1LMNA | |
| SCHEMBL3868044 | 0.88 | RXRA (0.43) | RXRARXRBRXRGALDH1A1LMNA | |
| SCHEMBL12272136 | 0.84 | RXRA (0.55) | RXRARXRBRXRGALDH1A1LMNA | |
| SCHEMBL156398 | 0.83 | RXRA (0.42) | RXRARXRBRXRGALDH1A1LMNA | |
| SCHEMBL31628652 | 0.83 | RXRA (0.42) | RXRARXRBRXRGALDH1A1LMNA | |
| SCHEMBL1193030 | 0.83 | RXRA (0.42) | RXRARXRBRXRGALDH1A1LMNA | |
| SCHEMBL29416187 | 0.83 | RXRA (0.42) | RXRARXRBRXRGALDH1A1LMNA | |
| SCHEMBL19502544 | 0.82 | RXRA (0.41) | RXRARXRBRXRGALDH1A1LMNA | |
| SCHEMBL4572292 | 0.81 | CYP4F2 (0.46) | RXRARXRBRXRGALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021018173-A1 | ADENOSINE RECEPTOR ANTAGONIST | 杭州阿诺生物医药科技有限公司 | 2021-02-04 | — | — | WO | disclosed |
| US-8404859-B2 | Thiazole and thiophene compounds | HOFFMANN-LA ROCHE INC. (US) | 2013-03-26 | — | — | US | disclosed |
| US-8404859-B2 | Thiazole and thiophene compounds | HOFFMANN-LA ROCHE INC. (US) | 2013-03-26 | — | — | US | disclosed |
| US-8404859-B2 | Thiazole and thiophene compounds | HOFFMANN-LA ROCHE INC. (US) | 2013-03-26 | — | — | US | disclosed |
| WO-2012123471-A1 | THIAZOLE AND THIOPHENE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-09-20 | — | — | WO | disclosed |
| WO-2012123471-A1 | THIAZOLE AND THIOPHENE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-09-20 | — | — | WO | disclosed |
| US-20120238569-A1 | THIAZOLE AND THIOPHENE COMPOUNDS | GILLESPIE PAUL (US) | 2012-09-20 | — | — | US | disclosed |
| US-20120238569-A1 | THIAZOLE AND THIOPHENE COMPOUNDS | GILLESPIE PAUL (US) | 2012-09-20 | — | — | US | disclosed |
| US-20120238569-A1 | THIAZOLE AND THIOPHENE COMPOUNDS | GILLESPIE PAUL (US) | 2012-09-20 | — | — | US | disclosed |
| US-7947728-B1 | Indole and indazole analogs as glycogen synthase activators | HOFFMANN-LA ROCHE INC. (US) | 2011-05-24 | — | — | US | disclosed |
| US-7491741-B2 | Diaminopropionic acid derivatives | HOFFMANN-LA ROCHE INC. (US) | 2009-02-17 | — | — | US | disclosed |
| US-20070155671-A1 | Diaminopropionic acid derivatives | FOTOUHI NADER | 2007-07-05 | — | — | US | disclosed |
| US-7217728-B2 | Diaminopropionic acid derivatives | HOFFMANN-LA ROCHE INC. (US) | 2007-05-15 | — | — | US | disclosed |
| US-20050080119-A1 | Diaminopropionic acid derivatives | FOTOUHI NADER (US) | 2005-04-14 | — | — | US | disclosed |
| US-6803384-B2 | FOR THERAPY OF REPERFUSION INJURY | HOFFMANN-LA ROCHE INC. | 2004-10-12 | — | — | US | disclosed |
| US-20040006236-A1 | Diaminopropionic acid derivatives | FOTOUHI NADER (US) | 2004-01-08 | — | — | US | disclosed |
| US-20020052512-A1 | Diaminopropionic acid derivatives | FOTOUHI NADER (US) | 2002-05-02 | — | — | US | disclosed |
| US-6331640-B1 | TREATMENT OF REPERFUSION INJURIES | HOFFMANN-LA ROCHE INC. | 2001-12-18 | — | — | US | disclosed |
| EP-1121342-A1 | DIAMINOPROPIONIC ACID DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-08-08 | — | — | EP | disclosed |
| WO-2000021920-A1 | DIAMINOPROPIONIC ACID DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-04-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040006236-A1 | Diaminopropionic acid derivatives | AIFM1, AIFM2, HIF1A | RXRA 1378/4885RXRB 1504/4885RXRG 1745/4885 |
| US-20020052512-A1 | Diaminopropionic acid derivatives | AIFM1, AIFM2, HIF1A | RXRA 1378/4885RXRB 1504/4885RXRG 1745/4885 |
| US-20070155671-A1 | Diaminopropionic acid derivatives | AIFM1, HIF1A, AIFM2 | RXRA 1154/4885RXRB 1185/4885RXRG 1388/4885 |
| US-20120238569-A1 | THIAZOLE AND THIOPHENE COMPOUNDS | TSLP, CFTR, TPMT | RXRA 730/4885RXRB 594/4885RXRG 686/4885 |
| US-20050080119-A1 | Diaminopropionic acid derivatives | AIFM1, HIF1A, AIFM2 | RXRA 1154/4885RXRB 1185/4885RXRG 1388/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.