Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | NEK2 | P51955 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ASPH | Q12797 | 1/20 | 0.36 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | AGER | Q15109 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1760587 | 0.81 | L3MBTL1 (0.39) | ALDH1A1ALOX15MAPK10HSD17B10L3MBTL1 | |
| SCHEMBL31736542 | 0.79 | HTR2C (0.44) | ALDH1A1KDM4E | |
| SCHEMBL30855570 | 0.79 | POLB (0.52) | ALDH1A1NEK2L3MBTL1KMT2AKDM4E | |
| SCHEMBL29563688 | 0.79 | CHIA (0.46) | ALDH1A1NEK2KMT2AMEN1 | |
| SCHEMBL5466087 | 0.79 | POLB (0.52) | ALDH1A1NEK2L3MBTL1KMT2AKDM4E | |
| SCHEMBL23536762 | 0.79 | HTR2C (0.44) | ALDH1A1KDM4E | |
| SCHEMBL2348152 | 0.79 | ALDH1A1 (0.48) | ALDH1A1NEK2ALOX15MAPK10HSD17B10 | |
| SCHEMBL874433 | 0.78 | L3MBTL1 (0.43) | ALDH1A1HSD17B10L3MBTL1KMT2AKDM4E | |
| SCHEMBL28535164 | 0.78 | L3MBTL1 (0.39) | ALDH1A1ALOX15HSD17B10L3MBTL1KMT2A | |
| SCHEMBL2339880 | 0.77 | L3MBTL1 (0.42) | ALDH1A1HSD17B10L3MBTL1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011057973-A1 | OXAZOLINE DERIVATIVES FOR TREATMENT OF CNS DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-05-19 | — | — | WO | disclosed |