Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.34 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.34 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3891024 | 0.86 | L3MBTL1 (0.43) | L3MBTL1MEN1KMT2ANPSR1ALDH1A1 | |
| SCHEMBL1760423 | 0.81 | ALDH1A1 (0.41) | L3MBTL1MEN1PKMKMT2ANPSR1 | |
| SCHEMBL394318 | 0.78 | OPRK1 (0.54) | L3MBTL1MEN1KMT2ANPSR1OPRK1 | |
| SCHEMBL26394011 | 0.77 | L3MBTL1 (0.39) | L3MBTL1NPSR1OPRK1KDM4E | |
| SCHEMBL2348152 | 0.74 | ALDH1A1 (0.48) | L3MBTL1KMT2ANPSR1ALDH1A1ALOX15 | |
| SCHEMBL9493845 | 0.73 | ADRA2A (0.43) | MEN1KMT2ANPSR1ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL9493835 | 0.72 | ADRA2A (0.42) | L3MBTL1MEN1KMT2ANPSR1ALDH1A1 | |
| SCHEMBL71518 | 0.72 | NPSR1 (0.59) | L3MBTL1NPSR1ALDH1A1KDM4EMAPT | |
| SCHEMBL15714879 | 0.70 | MYC (0.49) | L3MBTL1PKMNPSR1ALDH1A1HSD17B10 | |
| SCHEMBL18744958 | 0.68 | RAB9A (0.67) | L3MBTL1MEN1KMT2AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2499121-A1 | OXAZOLINE DERIVATIVES FOR TREATMENT OF CNS DISORDERS. | F. Hoffmann-La Roche AG (CH) | 2012-09-19 | — | — | EP | disclosed |
| WO-2011057973-A1 | OXAZOLINE DERIVATIVES FOR TREATMENT OF CNS DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-05-19 | — | — | WO | disclosed |