Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 1/20 | 0.62 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.62 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.62 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.62 |
| ▸ | PDE5A | O76074 | 3/20 | 0.53 |
| ▸ | PDE1A | P54750 | 3/20 | 0.53 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.53 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | PI4KA | P42356 | 3/20 | 0.44 |
| ▸ | PI4K2B | Q8TCG2 | 3/20 | 0.44 |
| ▸ | PI4K2A | Q9BTU6 | 3/20 | 0.44 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.44 |
| ▸ | PNP | P00491 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HCAR1 | Q9BXC0 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7431961 | 0.83 | GRIA1 (0.62) | GRIA1GRIA2GRIA3GRIA4PDE5A | |
| SCHEMBL14743926 | 0.83 | GRIA1 (0.62) | GRIA1GRIA2GRIA3GRIA4PDE5A | |
| SCHEMBL17604369 | 0.82 | GRIA1 (0.58) | GRIA1GRIA2GRIA3GRIA4PDE5A | |
| SCHEMBL1713327 | 0.82 | YTHDC1 (0.57) | GRIA1GRIA2GRIA3GRIA4PDE5A | |
| SCHEMBL4522031 | 0.80 | GRIA1 (0.58) | GRIA1GRIA2GRIA3GRIA4PDE5A | |
| SCHEMBL7439380 | 0.77 | CNOT7 (0.45) | GRIA1GRIA2GRIA3GRIA4PDE5A | |
| SCHEMBL6473284 | 0.74 | ADORA2A (0.54) | GRIA1GRIA2GRIA3GRIA4PI4KA | |
| SCHEMBL7437145 | 0.73 | GRIA1 (0.45) | GRIA1GRIA2GRIA3GRIA4PDE5A | |
| SCHEMBL17604230 | 0.73 | GRIA1 (0.51) | GRIA1GRIA2GRIA3GRIA4PDE5A | |
| SCHEMBL786455 | 0.73 | ADORA2A (0.49) | GRIA1GRIA2GRIA3GRIA4PI4KA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0538332-B1 | POLYCYCLIC GUANINE DERIVATIVES | SCHERING CORP (US) | 1997-07-23 | — | — | EP | disclosed |
| US-5393755-A | Hypotensive agents, enzyme inhibitors | SCHERING CORPORATION (US) | 1995-02-28 | — | — | US | disclosed |
| EP-0538332-A1 | POLYCYCLIC GUANINE DERIVATIVES. | SCHERING CORP (US) | 1993-04-28 | — | — | EP | disclosed |
| WO-1991019717-A1 | POLYCYCLIC GUANINE DERIVATIVES | SCHERING CORPORATION (US) | 1991-12-26 | — | — | WO | disclosed |