Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 5/20 | 0.40 |
| ▸ | KDM5A | P29375 | 2/20 | 0.40 |
| ▸ | PHF8 | Q9UPP1 | 6/20 | 0.39 |
| ▸ | KDM2B | Q8NHM5 | 3/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | HTR2B | P41595 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | KMO | O15229 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17604578 | 0.86 | KDM4C (0.40) | KDM4CKDM5APHF8KDM2BBRD4 | |
| SCHEMBL16095598 | 0.85 | KDM4C (0.56) | KDM4CKDM5APHF8KDM2BCYP2C9 | |
| SCHEMBL17604658 | 0.81 | KDM4C (0.43) | KDM4CKDM5APHF8KDM2BBRD4 | |
| SCHEMBL17604575 | 0.81 | PKM (0.42) | KDM4CKDM5APHF8KDM2BCYP2C9 | |
| SCHEMBL16095134 | 0.80 | KDM4C (0.60) | KDM4CKDM5APHF8KDM2B | |
| SCHEMBL17604535 | 0.74 | KDM4C (0.46) | KDM4CKDM5APHF8KDM2BBRD4 | |
| SCHEMBL17604536 | 0.72 | PHF8 (0.39) | KDM4CKDM5APHF8KDM2BPDE4D | |
| SCHEMBL17604553 | 0.72 | KDM4C (0.73) | KDM4CKDM5APHF8KDM2BBRD4 | |
| SCHEMBL17604525 | 0.72 | PHF8 (0.39) | KDM4CKDM5APHF8KDM2BPDE4D | |
| SCHEMBL16095351 | 0.70 | KDM4C (0.59) | KDM4CKDM5APHF8KDM2BKMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3193881-A1 | HISTONE DEMETHYLASE INHIBITORS | Celgene Quanticel Research, Inc. (US) | 2017-07-26 | — | — | EP | disclosed |
| WO-2016044342-A1 | HISTONE DEMETHYLASE INHIBITORS | Quanticel Pharmaceuticals, Inc. (US) | 2016-03-24 | — | — | WO | disclosed |