Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | NEK2 | P51955 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALPG | P10696 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | PHF8 | Q9UPP1 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17604537 | 0.81 | KDM4C (0.40) | ALDH1A1KMT2AHPGDPOLBMEN1 | |
| SCHEMBL17604573 | 0.80 | PKM (0.41) | PKML3MBTL1NEK2ALDH1A1KDM4E | |
| SCHEMBL17604623 | 0.79 | KDM4C (0.62) | PKML3MBTL1ALDH1A1KDM4EKMT2A | |
| SCHEMBL17604625 | 0.79 | KDM4C (0.62) | PKML3MBTL1ALDH1A1KDM4EKMT2A | |
| SCHEMBL16095598 | 0.78 | KDM4C (0.56) | KDM4CKDM5APHF8CYP2C9KDM2B | |
| SCHEMBL17604578 | 0.76 | KDM4C (0.40) | KDM4CKDM5APHF8KDM2B | |
| SCHEMBL16095270 | 0.71 | KDM4C (0.44) | KDM4C | |
| SCHEMBL17604658 | 0.71 | KDM4C (0.43) | KDM4CKDM5APHF8KDM2B | |
| SCHEMBL16095134 | 0.70 | KDM4C (0.60) | KDM4CKDM5APHF8KDM2B | |
| SCHEMBL16095351 | 0.66 | KDM4C (0.59) | KDM4CKDM5APHF8KDM2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3193881-A1 | HISTONE DEMETHYLASE INHIBITORS | Celgene Quanticel Research, Inc. (US) | 2017-07-26 | — | — | EP | disclosed |
| WO-2016044342-A1 | HISTONE DEMETHYLASE INHIBITORS | Quanticel Pharmaceuticals, Inc. (US) | 2016-03-24 | — | — | WO | disclosed |