Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 2/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.33 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.33 |
| ▸ | KMO | O15229 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.32 |
| ▸ | METAP1 | P53582 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16095813 | 0.87 | PHF8 (0.39) | JAK2TYK2HRH3IDH1KDM4C | |
| SCHEMBL16095079 | 0.87 | ADORA2A (0.39) | JAK2TYK2GRM5KDM4CNPY5R | |
| SCHEMBL16095540 | 0.84 | GRM5 (0.43) | MEN1KMT2AHRH3GRM5LRRK2 | |
| SCHEMBL16094887 | 0.82 | TSHR (0.37) | HRH3KCNH2GRM5IDH1NPY5R | |
| SCHEMBL16095066 | 0.81 | PHF8 (0.41) | GRM5KDM4C | |
| SCHEMBL16095102 | 0.79 | PHF8 (0.41) | TAAR1KDM4CNPY5R | |
| SCHEMBL17604542 | 0.77 | PHF8 (0.39) | TAAR1MEN1KMT2AKDM4C | |
| SCHEMBL16095040 | 0.75 | NPY5R (0.36) | KCNH2NPY5RMAP3K14METAP2METAP1 | |
| SCHEMBL16095484 | 0.74 | USP30 (0.38) | KCNH2NPY5RMAP3K14METAP2METAP1 | |
| SCHEMBL16095691 | 0.74 | FAAH (0.46) | KDM4CMETAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2969007-A1 | HISTONE DEMETHYLASE INHIBITORS | Quanticel Pharmaceuticals Inc (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014151945-A1 | HISTONE DEMETHYLASE INHIBITORS | Quanticel Pharmaceuticals, Inc. (US) | 2014-09-25 | — | — | WO | disclosed |