SCHEMBL1760632

SCHEMBL1760632

CN(C(=O)CC(=O)N(C)c1ccccc1)c1ccccc1

nearest known ligand 0.61

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.58
POLQ O75417 3/20 0.57
ALDH1A1 P00352 2/20 0.55
NPC1 O15118 1/20 0.53
RAB9A P51151 1/20 0.53
CYP3A4 P08684 1/20 0.53
CYP2C9 P11712 1/20 0.53
CYP2C19 P33261 1/20 0.53
NPSR1 Q6W5P4 1/20 0.53
MEN1 O00255 1/20 0.51
LMNA P02545 2/20 0.50
PPIB P23284 1/20 0.50
L3MBTL1 Q9Y468 1/20 0.50
HTT P42858 1/20 0.49
POLB P06746 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11819020 0.92 KMT2A (0.55) KMT2APOLQALDH1A1NPC1RAB9A
SCHEMBL307215 0.91 KMT2A (0.54) KMT2APOLQALDH1A1CYP3A4CYP2C9
SCHEMBL6659655 0.90 KMT2A (0.53) KMT2APOLQALDH1A1CYP3A4CYP2C9
SCHEMBL4593319 0.88 KMT2A (0.51) KMT2APOLQALDH1A1CYP3A4CYP2C9
SCHEMBL10202353 0.86 ALDH1A1 (0.56) KMT2APOLQALDH1A1CYP3A4CYP2C9
SCHEMBL28529919 0.86 KMT2A (0.58) KMT2APOLQALDH1A1NPC1RAB9A
SCHEMBL9675188 0.86 POLQ (0.50) KMT2APOLQALDH1A1NPC1RAB9A
SCHEMBL307080 0.86 KMT2A (0.50) KMT2APOLQALDH1A1CYP3A4CYP2C9
SCHEMBL19027030 0.85 ALDH1A1 (0.55) KMT2APOLQALDH1A1CYP3A4CYP2C9
SCHEMBL21480115 0.85 POLQ (0.49) KMT2APOLQALDH1A1CYP3A4CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2758416-B1 NICKEL CONTAINING HYDROSILYLATION CATALYSTS AND COMPOSITIONS CONTAINING THE CATALYSTS DOW CORNING (US) 2018-05-09 EP disclosed
US-9545624-B2 Nickel containing hydrosilylation catalysts and compositions containing the catalysts DOW CORNING CORPORATION (US) 2017-01-17 US disclosed
US-9545624-B2 Nickel containing hydrosilylation catalysts and compositions containing the catalysts DOW CORNING CORPORATION (US) 2017-01-17 US disclosed
US-9480977-B2 Ruthenium containing hydrosilylation catalysts and compositions containing the catalysts DOW CORNING CORPORATION (US) 2016-11-01 US disclosed
US-9480977-B2 Ruthenium containing hydrosilylation catalysts and compositions containing the catalysts DOW CORNING CORPORATION (US) 2016-11-01 US disclosed
US-9328205-B2 Iron(III) containing complex and condensation reaction catalysts, methods for preparing the catalysts, and compositions containing the catalysts DOW CORNING CORPORATION (US) 2016-05-03 US disclosed
US-9328205-B2 Iron(III) containing complex and condensation reaction catalysts, methods for preparing the catalysts, and compositions containing the catalysts DOW CORNING CORPORATION (US) 2016-05-03 US disclosed
US-9221041-B2 Iridium containing hydrosilylation catalysts and compositions containing the catalysts DOW CORNING CORPORATION (US) 2015-12-29 US disclosed
US-9221041-B2 Iridium containing hydrosilylation catalysts and compositions containing the catalysts DOW CORNING CORPORATION (US) 2015-12-29 US disclosed
US-20140371056-A1 Iron(III) Containing Complex and Condensation Reaction Catalysts, Methods for Preparing the Catalysts, and Compositions Containing the Catalysts DOW COMING CORPORATION (US) 2014-12-18 US disclosed
US-20140206869-A1 Iridium Containing Hydrosilylation Catalysts and Compositions Containing the Catalysts DOW SILICONES CORPORATION 2014-07-24 US disclosed
US-20140206869-A1 Iridium Containing Hydrosilylation Catalysts and Compositions Containing the Catalysts DOW SILICONES CORPORATION 2014-07-24 US disclosed
US-20140183398-A1 Nickel Containing Hydrosilylation Catalysts and Compositions Containing the Catalysts DOW SILICONES CORPORATION 2014-07-03 US disclosed
US-20140183398-A1 Nickel Containing Hydrosilylation Catalysts and Compositions Containing the Catalysts DOW SILICONES CORPORATION 2014-07-03 US disclosed
US-8609898-B2 Separation reagent of platinum group metal, method for separating and recovering platinum group metal, and amide-containing tertiary amine compound NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) 2013-12-17 US disclosed
WO-2013052585-A2 IRON(III) CONTAINING COMPLEX AND CONDENSATION REACTION CATALYSTS, METHODS FOR PREPARING THE CATALYSTS, AND COMPOSITIONS CONTAINING THE CATALYSTS DOW CORNING CORPORATION (US) 2013-04-11 WO disclosed
WO-2013043787-A2 RUTHENIUM CONTAINING HYDROSILYLATION CATALYSTS AND COMPOSITIONS CONTAINING THE CATALYSTS DOW CORNING CORPORATION (US) 2013-03-28 WO disclosed
WO-2013043785-A2 NICKEL CONTAINING HYDROSILYLATION CATALYSTS AND COMPOSITIONS CONTAINING THE CATALYSTS DOW CORNING CORPORATION (US) 2013-03-28 WO disclosed
US-20110113927-A1 SEPARATION REAGENT OF PLATINUM GROUP METAL, METHOD FOR SEPARATING AND RECOVERING PLATINUM GROUP METAL, AND AMIDE-CONTAINING TERTIARY AMINE COMPOUND NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) 2011-05-19 US disclosed
US-20100095807-A1 SEPARATION REAGENT OF PLATINUM GROUP METAL, METHOD FOR SEPARATING AND RECOVERING PLATINUM GROUP METAL, AND AMIDE-CONTAINING TERTIARY AMINE COMPOUND NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) 2010-04-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140206869-A1 Iridium Containing Hydrosilylation Catalysts and Compositions Containing the Catalysts ILK, ALG8, HIRA KMT2A 2310/4885POLQ 2226/4885ALDH1A1 1484/4885
US-20100095807-A1 SEPARATION REAGENT OF PLATINUM GROUP METAL, METHOD FOR SEPARATING AND RECOVERING PLATINUM GROUP METAL, AND AMIDE-CONTAINING TERTIARY AMINE COMPOUND AOC1, HRH3, HRH2 KMT2A 1456/4885POLQ 2109/4885ALDH1A1 289/4885
US-20140183398-A1 Nickel Containing Hydrosilylation Catalysts and Compositions Containing the Catalysts HIRA, ALG8, CAD KMT2A 1098/4885POLQ 2247/4885ALDH1A1 2299/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.