Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 3/20 | 0.39 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | APLNR | P35414 | 2/20 | 0.34 |
| ▸ | C1S | P09871 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.33 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1761049 | 0.80 | MGLL (0.42) | MGLLAGTR2ALDH1A1RAB9ALMNA | |
| SCHEMBL3053848 | 0.75 | OGA (0.40) | MGLLAGTR2PIK3CDALDH1A1KDM4E | |
| Trifluoroacetic Acid SCHEMBL1760939 | 0.73 | ADORA2A (0.39) | ALDH1A1KDM4E | |
| SCHEMBL2931850 | 0.72 | RAB9A (0.54) | AGTR2ALDH1A1RAB9ALMNAMAPT | |
| Trifluoroacetic Acid SCHEMBL1761010 | 0.71 | ADORA2A (0.39) | — | |
| Trifluoroacetic Acid SCHEMBL1760996 | 0.71 | ADRA1A (0.40) | — | |
| Trifluoroacetic Acid SCHEMBL2933045 | 0.69 | ADORA2A (0.34) | ALDH1A1KDM4EMAPTSMN1; SMN2HTT | |
| Trifluoroacetic Acid SCHEMBL1760931 | 0.68 | — | — | |
| SCHEMBL4054003 | 0.66 | ADORA2A (0.41) | ALDH1A1MAPT | |
| SCHEMBL1761037 | 0.66 | ADORA2A (0.61) | LMNAMAPTSMN1; SMN2NPC1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7947692-B2 | Substituted thiazolo[5,4-d]pyrimidine urea derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-05-24 | — | — | US | disclosed |