Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 16/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 14/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.34 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1761065 | 0.95 | ADORA2A (0.40) | ADORA2AADORA1ADORA2BADORA3FAAH | |
| Trifluoroacetic Acid SCHEMBL1760939 | 0.84 | ADORA2A (0.39) | ADORA2AADORA1ADORA2BADORA3 | |
| SCHEMBL3051009 | 0.84 | OGA (0.36) | ADORA2AADORA1ADORA3 | |
| Trifluoroacetic Acid SCHEMBL1760996 | 0.82 | ADRA1A (0.40) | ADORA2AADORA1ADORA2B | |
| Trifluoroacetic Acid SCHEMBL1760931 | 0.82 | — | — | |
| SCHEMBL1761049 | 0.80 | MGLL (0.42) | ADORA2AADORA1ADORA2BFAAH | |
| Trifluoroacetic Acid SCHEMBL1760936 | 0.79 | PKM (0.40) | ADORA2AADORA1ADORA2BADORA3 | |
| SCHEMBL4054003 | 0.78 | ADORA2A (0.41) | ADORA2AADORA1ADORA3 | |
| Trifluoroacetic Acid SCHEMBL1761052 | 0.78 | ACHE (0.46) | FAAH | |
| SCHEMBL1761037 | 0.77 | ADORA2A (0.61) | ADORA2AADORA1ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7947692-B2 | Substituted thiazolo[5,4-d]pyrimidine urea derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-05-24 | — | — | US | disclosed |