Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | MPL | P40238 | 1/20 | 0.37 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 4/20 | 0.36 |
| ▸ | NOS2 | P35228 | 3/20 | 0.36 |
| ▸ | FEN1 | P39748 | 3/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.36 |
| ▸ | NOS1 | P29475 | 3/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17610099 | 0.74 | ASIC3 (0.44) | ASIC3BACE1KDM1APIK3CD | |
| SCHEMBL26522084 | 0.74 | ASIC3 (0.42) | ASIC3NOS3NOS2FEN1ALOX5AP | |
| SCHEMBL26650965 | 0.72 | MET (0.48) | METCYP2C19ADORA2AADORA1 | |
| SCHEMBL18039077 | 0.72 | ASIC3 (0.47) | ASIC3ADORA2AADORA1BACE1KDM1A | |
| SCHEMBL17619753 | 0.70 | ASIC3 (0.45) | ASIC3NOS3NOS2ALOX5APKDM1A | |
| SCHEMBL6256565 | 0.69 | CTSS (0.60) | ASIC3ADORA2AADORA1BRD4KDM1A | |
| SCHEMBL30797381 | 0.69 | CYP1A2 (0.43) | CYP1A2CYP3A4CYP2C19NOS3NOS2 | |
| SCHEMBL573513 | 0.69 | CYP1A2 (0.43) | CYP1A2CYP3A4CYP2C19NOS3NOS2 | |
| SCHEMBL29464843 | 0.69 | SCN9A (0.40) | METSCN9AMPLCYP1A2CYP3A4 | |
| SCHEMBL28715902 | 0.69 | SCN9A (0.40) | METSCN9AMPLCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3193880-A1 | INHIBITING THE TRANSIENT RECEPTOR POTENTIAL A1 ION CHANNEL | Hydra Biosciences, Inc. (US) | 2017-07-26 | — | — | EP | disclosed |
| WO-2016044792-A1 | INHIBITING THE TRANSIENT RECEPTOR POTENTIAL A1 ION CHANNEL | HYDRA BIOSCIENCES, INC. (US) | 2016-03-24 | — | — | WO | disclosed |